26107-80-2

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZOATE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to enhance the properties of the final drug products, such as stability and efficacy.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZOATE is utilized as a component in the development of pesticides and other agrochemicals, leveraging its stability and reactivity to improve the performance of these products.
Used in Fragrance Industry:
METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZOATE is employed as a building block in the creation of fragrances, where its unique properties can contribute to the development of novel scents and improve the longevity of fragrances.
Used in Organic Synthesis:
METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZOATE is used as a reactant in various organic synthesis reactions due to its reactivity and the presence of trifluoromethyl groups, which can be further modified to produce a range of chemical products.
Used in Material Science:
METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZOATE is utilized in the preparation of novel materials, taking advantage of its thermal stability and resistance to oxidation, which are desirable traits in material development.

InChI:InChI=1/C10H6F6O2/c1-18-8(17)5-2-6(9(11,12)13)4-7(3-5)10(14,15)16/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 401-96-7 3,5-bis(trifluoromethyl)benzoyl fluoride 
• 201230-82-2 carbon monoxide 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 725-89-3 3,5-bistrifluoromethylbenzoic acid 

Downstream Products

• 334477-34-8 C₁₅H₁₁F₆NO₂ 
• 32707-89-4 3,5-bis(trifluoromethyl)benzenemethanol 
• 26107-82-4 3,5-bis-(trifluoromethyl)benzoic acid hydrazide 
• 167853-55-6 4-[3-(3,5-Bis-trifluoromethyl-phenyl)-3-hydroxy-propyl]-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 167853-54-5 4-[3-(3,5-Bis-trifluoromethyl-phenyl)-3-oxo-propyl]-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 167853-52-3 [2-(3,5-Bis-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester 

Relevant academic research and scientific papers

AMINO ALCOHOL DERIVATIVE, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

The present invention belongs to the field of medicine, and specifically discloses an amino alcohol derivative represented by Formula I, a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. In addition, the present invention also discloses a pharmaceutical composition comprising the above substances, and a use of the substance in the preparation of a medicament for the prevention and treatment of an immune inflammatory disease, or a disease or condition associated with immunological competence such as multiple sclerosis, ALS, CIDP, systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, psoriasis, polymyositis, etc.

Method for producing carboxylic acids (by machine translation)

[Problem] to obtain, by a flow transition metal catalyst using a column filled with a carbonylation reaction, contamination of the reaction products to achieve mixing of the metal catalyst. [Solution] the presence of the ligand and, having the general formula (1) R-to-X(wherein, R is (C1 - C10 ) Aryl group, a heterocyclic group, X is a halogen atom, or OSO2 CF3 In. ) As shown in matrix, a transition metal catalyst, a ligand, and basic solution dissolved in a solvent uniformly supported palladium catalyst was filled in a carrier by reacting flow reactor, general formula (2): RCO-a Z (in the formula, R is the same comb, Z is hydroxyl group or the like. ) A carbonyl compound represented by environmentally safely and efficiently. Figure 1 [drawing] (by machine translation)

The production of the carboxylic acid (by machine translation)

PROBLEM TO BE SOLVED: carbon monoxide which is a toxic gas Nonstoichiometrically controlling environmentally safe and efficient reaction can be done in a continuous-flow system [...] reaction using a transition metal catalyst. SOLUTION: a continuous-flow system, carbon monoxide, eq. (1) R-X (in the formula, R is (C 1-C 10) aryl group, X is a halogen atom or OSO 2 CF 3. ) Compound, a transition metal catalyst, ligand, dissolved in a solvent and a base are uniformly mixed in the retention unit soln. by reaction, eq. (2): RCO-Z (in the formula, R and the p.then, Z is hydroxyl or the l ) Represented by a safe and environmentally friendly calbonyl compd.. Selected drawing: no (by machine translation)

HIGH-PURITY (FLUOROALKYL)BENZENE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME

The process for producing a (fluoroalkyl)benzene derivative according to the present invention comprises a step of reducing the total content of group 3 to group 12 transition metals in an alkylbenzene derivative to 500 ppm or less in terms of metal atoms; a step of halogenating the branched alkyl group of the purified alkylbenzene derivative by a photohalogenation to obtain a (haloalkyl)benzene derivative; and a step of subjecting the (haloalkyl)benzene derivative to a halogen-fluorine exchange using HF in an amount of 10 mol or higher per one mole of the (haloalkyl)benzene derivative. The (fluoroalkyl)benzene derivative produced by the process is reduced in the content of impurities such as residual halogens and residual metals, and is useful as intermediates for functional chemical products for use in applications such as medicines and electronic materials.