261159-27-7

Basic information

• Product Name: 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one
• Synonyms: 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one
• CAS NO: 261159-27-7
• Molecular Weight: 605.65
• Mol File: 261159-27-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one(261159-27-7)
• EPA Substance Registry System: 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one(261159-27-7)

Safety Data

• Hazardous Substances Data: 261159-27-7(Hazardous Substances Data)

Upstream product

• 103408-45-3 pyrimido[1,2-a]purin-10(3H)-one 
• 635-39-2 Guanine hydrochloride 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 87171-83-3 3-(2-deoxy-β-D-erythropentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine 

Relevant articles and documents

Synthesis of oligonucleotides containing the alkali-labile pyrimidopurinone adduct, M1G

An improved method for the synthesis of oligodeoxyribonucleotides containing the endogenous adduct, pyrimido[1,2-a]purin-10(3H)-one (M1G), is reported. The key features of the methodology include improved synthesis of the deoxynucleoside of M1G by transribosylation with deoxycytidine catalyzed by nucleoside 2'-deoxyribosyltransferase and the use of commercially available 4-tert-butylphenoxyacetyl protecting groups for normal nucleotides. Facile deprotection and removal of the M1G-containing oligomers from the solid support were achieved by treatment with a solution of potassium carbonate in methanol. NMR studies were performed to determine the stability of the oligonucleotides at different pHs.