261176-52-7Relevant articles and documents
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors
Lau, Cheuk K.,Bayly, Christopher I.,Gauthier, Jacques Yves,Li, Chun Sing,Therien, Michel,Asante-Appiah, Ernest,Cromlish, Wanda,Boie, Yves,Forghani, Farnaz,Desmarais, Sylvie,Wang, Qingping,Skorey, Kathryn,Waddleton, Deena,Payette, Paul,Ramachandran, Chidambaram,Kennedy, Brian P.,Scapin, Giovana
, p. 1043 - 1048 (2004)
A series of benzotriazole phenyldifluoromethylphosphonic acids were found to be potent PTP-1B inhibitors. Molecular modeling on the X-ray crystal structure of the lead structure led to the design of potent PTP-1B inhibitors that show moderate selectivity against TC-PTP, a very closely related protein tyrosine phosphatase.
