Bioorganic and Medicinal Chemistry Letters p. 1043 - 1048 (2004)
Update date:2022-08-03
Topics:
Lau, Cheuk K.
Bayly, Christopher I.
Gauthier, Jacques Yves
Li, Chun Sing
Therien, Michel
Asante-Appiah, Ernest
Cromlish, Wanda
Boie, Yves
Forghani, Farnaz
Desmarais, Sylvie
Wang, Qingping
Skorey, Kathryn
Waddleton, Deena
Payette, Paul
Ramachandran, Chidambaram
Kennedy, Brian P.
Scapin, Giovana
A series of benzotriazole phenyldifluoromethylphosphonic acids were found to be potent PTP-1B inhibitors. Molecular modeling on the X-ray crystal structure of the lead structure led to the design of potent PTP-1B inhibitors that show moderate selectivity against TC-PTP, a very closely related protein tyrosine phosphatase.
View MoreJiangxi Dongxu Chemical Science & Technology Co.,Ltd
Contact:+86-791-86899381
Address:Nanchang, Jiangxi, China
Contact:+(852) 301-98033
Address:Flat C, 23/F, Lucky Plaza, 315-321 Lockhart Road, Wan Chai, Hong Kong
website:http://www.shtopchem.com/
Contact:0086-0576-87776998
Address:room no 1608,xuhui business building yude road,xujiahui street, xuhui district
Wuhan Fortuna Chemical Co.,Ltd
website:http://www.fortunachem.com
Contact:86-27-59207850
Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China
JIANGXI XINXIN CHEMICAL CO., LTD.
Contact:86-15957176628
Address:INDUSTRY ROAD 1, INDUSTRIAL PARK, HEKOU TOWN,YANSHAN COUNTY, JIANGXI PROVINCE, CHINA
Doi:10.1007/BF00761013
()Doi:10.1016/S0020-1693(02)01236-7
(2003)Doi:10.1039/JR9280000591
()Doi:10.1007/s10895-019-02382-4
(2019)Doi:10.1021/acs.joc.5b00418
(2015)Doi:10.1002/cber.19701030322
(1970)