26118-68-3 Usage
Uses
Used in Pharmaceutical Industry:
ISOBUTYLSULFAMOYL CHLORIDE is used as a reagent for the synthesis of pharmaceuticals, facilitating the production of various medicinal compounds. Its ability to act as a protecting group for amines is crucial in ensuring the selective formation of desired products, thereby enhancing the efficiency and specificity of pharmaceutical manufacturing processes.
Used in Organic Synthesis:
In the realm of organic synthesis, ISOBUTYLSULFAMOYL CHLORIDE is utilized as a key intermediate for the creation of sulfamoyl compounds. These compounds are valuable for their diverse applications, including the development of new drugs and the modification of existing ones to improve their therapeutic properties.
Used in Chemical Research:
ISOBUTYLSULFAMOYL CHLORIDE is also employed in chemical research as a tool to explore the reactivity and properties of amines and other functional groups. Its use in this context aids in advancing the understanding of chemical reactions and the development of new synthetic methodologies.
Used in Industrial Applications:
Beyond its pharmaceutical and research applications, ISOBUTYLSULFAMOYL CHLORIDE finds use in various industrial processes. Its role as a precursor for sulfamoyl compounds makes it instrumental in the production of specialty chemicals, agrochemicals, and other industrial products that rely on the unique properties of these compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 26118-68-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,1,1 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 26118-68:
(7*2)+(6*6)+(5*1)+(4*1)+(3*8)+(2*6)+(1*8)=103
103 % 10 = 3
So 26118-68-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H10ClNO2S/c1-4(2)3-6-9(5,7)8/h4,6H,3H2,1-2H3
26118-68-3Relevant academic research and scientific papers
Orally active isoxazoline glycoprotein IIb/IIIa antagonists with extended duration of action
Olson, Richard E.,Sielecki, Thais M.,Wityak, John,Pinto, Donald J.,Batt, Douglas G.,Frietze, William E.,Liu, Jie,Tobin, A. Ewa,Orwat, Michael J.,Di Meo, Susan V.,Houghton, Gregory C.,Lalka, George K.,Mousa, Shaker A.,Racanelli, Adrienne L.,Hausner, Elizabeth A.,Kapil, Ram P.,Rabel, Shelley R.,Thoolen, Martin J.,Reilly, Thomas M.,Anderson, Paul S.,Wexler, Ruth R.
, p. 1178 - 1192 (2007/10/03)
Modification of the α-carbamate substituent of isoxazoline GPIIb/IIIa (α(IIb)β3) antagonist DMP 754 (7) led to a series of α-sulfonamide and α-sulfamide diaminopropionate isoxazolinylacetamides which were found to be potent inhibitors of in vitro platelet aggregation. Aryl- and heteroaryl-α- sulfonamide groups, in conjunction with (5R)-isoxazoline (2S)- diaminopropionate stereochemistry, were found to impact a pronounced duration of antiplatelet effect in dogs, potentially due to high affinity for unactivated platelets. Isoxazolylsulfonamide 34b (DMP 802), a highly selective GPIIb/IIIa antagonist, demonstrated a prolonged duration of action after iv and po dosing and high affinity for resting and activated platelets. The prolonged antiplatelet profile of DMP 802 in dogs and the high affinity of DMP 802 for human platelets may be predictive of clinical utility as a once-daily antiplatelet agent.
