26124-78-7

Basic information

• Product Name: POLY-L-LYSINE HYDROCHLORIDE
• Synonyms: POLY-L-LYSINE HYDROCHLORIDE;poly-L-lysine hydrochloride mol. wt.*15,000-30,00;POLY-L-LYSINE HYDROCHLORIDE MOL. WT.*15, 000-30,000;Poly-(L-Lysinehydrochloridemwlargerthan20000;Poly-l-lysineHClmwlargerthan20000;L-Lysine, monohydrochloride, homopolymer;L-Lysine hydrochloride homopolymer;POLY-L-LYSINE HYDROCHLORIDE MOL. WT.
• CAS NO: 26124-78-7
• Molecular Formula: (C6H14N2O2)x.(HCl)x
• Product Categories: Amino Acids;Homopolymers;Polyamino Acids
• Mol File: 26124-78-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: POLY-L-LYSINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: POLY-L-LYSINE HYDROCHLORIDE(26124-78-7)
• EPA Substance Registry System: POLY-L-LYSINE HYDROCHLORIDE(26124-78-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 26124-78-7(Hazardous Substances Data)

Usage

Uses

Poly-L-lysine hydrochloride has been used to coat glass slides and coverslips to facilitate cell attachment.

Biochem/physiol Actions

L-Lysine is believed to prevent osteoporosis of bones, which is a characteristics of vascular calcification. Glutaric aciduria type I and pyridoxine-dependent epilepsy occurs due to lack of L-lysine catabolic pathway. Lysine participates in the regulation of NO (nitric oxide) synthesis. It possesses antiviral activity, therefore it is used in the treatment of Herpes simplex. L-Lysine is associated with a number of biochemical reactions such as acetylation, O-linked glycosylation, ubiquitination and protein methylation. Poly-L-lysine is considered as a biocompatible polymer and serves for the purpose of drug delivery across cell membrane. It is useful as one of the nanosized contrast agents in MRI (magnetic resonance imaging).

Upstream product

• 2280-44-6 D-Glucose 
• 129243-87-4 4-<(2R,5S)-2,5-Dihydro-2-isopropyl-3,6-dimethoxy-5-pyrazinyl>butylamine 
• 118477-18-2 N-acetyl-cyclolysine 
• 118477-05-7 Isobengamide E 
• 129243-83-0 4-<(2R,5S)-2,5-Dihydro-2-isopropyl-3,6-dimethoxy-5-pyrazinyl>butyronitrile 
• 7732-18-5 water 
• 923-27-3 D-lysine 
• 6804-88-2 α-nitrocaprolactam 
• 70-53-1 2,6-Diamino-hexanoic acid; hydrochloride 

Downstream Products

• 42294-60-0 Lys(2,4-Cl₂-Z) 
• 42294-61-1 N^ε-(2,6-Dichlorbenzyloxycarbonyl)-L-lysin 
• 42390-97-6 N^ε-(2-Chlorophenylmethoxycarbonyl)-(S)-lysine 
• 42294-62-2 N^ε-(3,4-Dichlorbenzyloxycarbonyl)-L-lysin 
• 55836-53-8 (S)-(-)-Ethyl-N(α),N(α),N(ε),N(ε)-Tetramethyl-lysinat 
• 6416-98-4 N^α-Formyl-N^ε-benzyloxycarbonyl-lys 
• 31202-69-4 N_ε-(tert-butoxycarbonyl)-D-lysine 
• 103005-72-7 N^ε-(6,8-Dibenzylthio-octanoyl)-L-lysin 
• 53608-77-8 (4S,4'S)-5,5,5',5'-tetramethyl-2t,2't'-[(1R,4S,11R)-4-carboxy-2,10-dioxo-1,11-bis-(2-phenyl-acetylamino)-3,9-diaza-undecane-1,11-diyl]-bis-thiazolidine-4r-carboxylic acid 
• 212185-11-0 N^ε-Tosyl-lysin 
• 21622-84-4 N^ε-(4-Chlorbenzyloxycarbonyl)-L-lysin 
• 2483-48-9 (+)-(S)-N₂,N₆-bis[(1,1-dimethylethoxy)carbonyl]-lysine methyl ester 
• 97347-29-0 Boc-Lys(Boc)-O-NBzl 
• 53706-02-8 (S)-1-carboxy-5-(1,3-dioxoisoindolin-2-yl)pentan-1-aminium chloride 

Relevant articles and documents

Chiral Receptors for Lysine Based on Covalently Linked Bis- and Tris-binaphthylphosphoric Acids

The synthesis and application of three chiral receptors based on the covalent linkage of 1,1′-binaphthylphosphoric acids is reported. The binding of the lysine enantiomers to the chiral receptors was investigated by DOSY-NMR and NMR titrations, revealing that the bisphosphoric acid 1d acts as a highly stereoselective receptor for binding of d-lysine.

Polyunsaturated fatty acid derivatives, pharmaceutical compositions containing the same, method for the preparation thereof, and their use as medicament

The compounds of the Formula (I) STR1 wherein R1 is a C18-24 alkenyl containing at least two double bonds, or --(CH2)n --CH(NH2)m --COOH X is 0, NH or C1-4 alkyl-N, Y is CONH2, COOH or COOMe, wherein Me is hydrogen metal, and R2 is a side chain of a any amino acid except L-GLU or L-ASP at α-position or a group of Formula wherein k is zero or an integer of 1, n is zero or an integer of 1 to 3, m is zero or an integer of 1 to 4, A is hydroxyl or one A is hydroxyl and the other A is hydrogen. M is H or R1 --CO and X and R1 are as defined above and their salts having tyrosine kinase inhibitor activity can be used as antitumor agents.

Enantioselective synthesis of isotopically labelled α-amino acids. Preparation of (ε-13C)-L-α-aminoadipic acid and five isotopomers of L-lysine with 13C, 15N and 2H in the δ and ε-positions

An asymmetric synthesis of the six-carbon α-amino acids (ε-13C)-L-α-aminoadipic acid and various isotopomers of L-lysine is described.The synthesis is based on a general method starting from the bis-lactim ether of cyclo(D-Val-Gly) and simple labelled reagents like K(13)CN, K(13)C15N, (13)CH3CN and LiAl(2)H4.Using this route (ε-13C)-L-α-aminoadipic acid was prepared in 31percent yield based on the labelled potassium cyanide.Five different isotopomers of L-lysine were prepared in high overall yield (45percent based on the labelled starting compound): (ε-13C)-L-lysine,(ε-13C,ε-15N)-L-lysine, (δ-13C)-L-lysine, (ε-2H2)-L-lysine and (ε-13C,ε-2H2)-L-lysine.The isotopomers were characterized using various spectroscopic techniques, e.g., 1H NMR, 2H NMR, 13C NMR, 15N NMR and mass spectrometry.The 31.2-ppm and the 27.6-ppm peak in the 13C NMR spectrum of lysine could be unambiguously assigned to the β- and δ-carbons, respectively.This means that the assignment previously reported is incorrect.