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118477-18-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 118477-18-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,4,7 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 118477-18:
142 % 10 = 2
So 118477-18-2 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017


1.1 GHS Product identifier

Product name N-acetylcyclolysine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:118477-18-2 SDS

118477-18-2Downstream Products

118477-18-2Relevant articles and documents

Preparation, characterization, DNA binding, and in Vitro cytotoxicity of the enantiomers of the platinum(II) complexes N-methyl-, N-ethyl- and N,N- dimethyl-(R)- and -(S)-3-aminohexahydroazepinedichloroplatinum(II)

Rezler, Evonne M.,Fenton, Ronald R.,Esdale, Warren J.,McKeage, Mark J.,Russell, Pamela J.,Hambley, Trevor W.

, p. 3508 - 3515 (1997)

A series of chiral diaminedichloroplatinum(II) complexes derived from [Pt(ahaz)Cl2] (ahaz = 3-aminohexahydroazepine) have been synthesized and tested for cytotoxic activity. Novel synthetic pathways were developed to produce the structural derivatives of the ahaz ligand, with alkyl substituents on the exocyclic nitrogen atom. The platinum(II) complexes of these ligands were synthesized and characterized by NMR and CD spectroscopy, confirming isomeric and enantiomeric purity. The crystal structures of three of these complexes, [Pt(S-meahaz)Cl2], [Pt(R-etahaz)Cl2], and [Pt(S- dimeahaz)Cl2] (meahaz = N-methylahaz, etahaz = N-ethylahaz, dimeahaz = N,N- dimethylahaz), have been determined to establish the orientation of the protons and alkyl substituents on the nitrogen donor atoms. In vitro assays of the cytotoxic activity of the complexes have revealed a significant and reproducible enantioselective trend with the R-enantiomers more active than the S-enantiomers in all cell lines. Increasing the steric bulk on the amine groups was found to have only a modest effect on activity. No enantioselectivity was observed in the binding of R- and S-[Pt(etahaz)Cl2] to calf-thymus DNA.

Syntesis and Amnesia-Reversal Activity of a Series of 7- and 5-Membered 3-Acylamino Lactams

Angelucci, Luciano,Calvisi, Pina,Catini, Roberto,Cosentino, Ugo,Cozzolino, Roberto,et al.

, p. 1511 - 1519 (2007/10/02)

A series of 3-(acylamino)-ε-caprolactams and 3-(acylamino)-2-pyrrolidinones was synthesized.Some of these compounds reversed at different degrees electroconvulsive shock- and Scopolamine-induced amnesia, using a step-through passive avoidance in mice.Classical nootropic drugs, i.e., Aniracetam, Oxiracetam, and Piracetam, were used as reference compounds.Within the analyses of data performed, we introduced a new parameter, the confrontation index (CI), which is a function of Mann-Whitney's U statistic.The CI permits a common scale of activity of substances to be generated, independently of probabilistic hypotheses, with higher scores representing higher activities.The most active compounds were characterized by the formylamino and amino groups in the 3-position of the ring.None of the substances assayed showed any effect on spontaneous behavior and neurovegetative system.

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