26131-20-4

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 1122-82-3 isothiocyanatocyclohexane 
• 931-53-3 Cyclohexyl isocyanide 

Downstream Products

• 38942-57-3 3-mercapto-4-cyclohexyl-5-phenyl-4H-1,2,4-triazole 
• 135276-19-6 4-Cyclohexyl-3-methylsulfanyl-5-phenyl-4H-[1,2,4]triazole 
• 135276-20-9 4-Cyclohexyl-3-ethylsulfanyl-5-phenyl-4H-[1,2,4]triazole 
• 135275-98-8 3-Allylsulfanyl-4-cyclohexyl-5-phenyl-4H-[1,2,4]triazole 
• 135276-21-0 4-Cyclohexyl-3-isopropylsulfanyl-5-phenyl-4H-[1,2,4]triazole 
• 948213-42-1 3-(2-propynyl)thio-4-cyclohexyl-5-phenyl-4H-1,2,4-triazole 
• 135276-22-1 3-Butylsulfanyl-4-cyclohexyl-5-phenyl-4H-[1,2,4]triazole 
• 135276-23-2 3-Benzylsulfanyl-4-cyclohexyl-5-phenyl-4H-[1,2,4]triazole 
• 135276-11-8 Butyl-[4-(4-cyclohexyl-5-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-but-2-ynyl]-methyl-amine 
• 135276-10-7 4-Cyclohexyl-3-phenyl-5-(4-pyrrolidin-1-yl-but-2-ynylsulfanyl)-4H-[1,2,4]triazole 
• 135276-09-4 1-[4-(4-Cyclohexyl-5-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-but-2-ynyl]-piperidine 
• 135276-12-9 4-[4-(4-Cyclohexyl-5-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-but-2-ynyl]-morpholine 
• 135276-13-0 1-[4-(4-Cyclohexyl-5-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-but-2-ynyl]-2-methyl-piperidine 
• 135276-15-2 1-[4-(4-Cyclohexyl-5-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-but-2-ynyl]-azepane 

Relevant academic research and scientific papers

Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β- d -ribofuranose 2′-Oxidase

We report herein the discovery of 3,5-dinitrophenyl 1,2,4-triazoles with excellent and selective antimycobacterial activities against Mycobacterium tuberculosis strains, including clinically isolated multidrug-resistant strains. Thorough structure-activity relationship studies of 3,5-dinitrophenyl-containing 1,2,4-triazoles and their trifluoromethyl analogues revealed the key role of the position of the 3,5-dinitrophenyl fragment in the antitubercular efficiency. Among the prepared compounds, the highest in vitro antimycobacterial activities against M. tuberculosis H37Rv and against seven clinically isolated multidrug-resistant strains of M. tuberculosis were found with S-substituted 4-alkyl-5-(3,5-dinitrophenyl)-4H-1,2,4-triazole-3-thiols and their 3-nitro-5-(trifluoromethyl)phenyl analogues. The minimum inhibitory concentrations of these compounds reached 0.03 μM, which is superior to all the current first-line anti-tuberculosis drugs. Furthermore, almost all compounds with excellent antimycobacterial activities exhibited very low in vitro cytotoxicities against two proliferating mammalian cell lines. The docking study indicated that these compounds acted as the inhibitors of decaprenylphosphoryl-β-d-ribofuranose 2′-oxidase enzyme, which was experimentally confirmed by two independent radiolabeling experiments.

Synthesis, anti-inflammatory, antimicrobial potential and molecular docking studies of 4,5-disubstituted-1,2,4-triazole thioacetate derivatives

Background: In the present study synthesis and biological assessment of nine new ethyl [(4,5-disubstituted-4H-1,2,4-triazol-3-yl)sulfanyl]acetate derivatives 2(a-i) is performed. Methods: The title compounds were characterized by their analytical and spec

Synthesis of 2-Amino-1,3,4-oxadiazoles through Elemental Sulfur Promoted Cyclization of Hydrazides with Isocyanides

A novel sulfur-promoted cyclization of hydrazides and isonitriles to produce 1,3,4-oxadiazole has been developed. The method is operationally simple and compatible with a wide scope of substrates and various 2-amino- 1,3,4-oxadiazoles are efficiently obtained in good yields.

Efficient and mild synthesis of substituted 2-amino-1,3,4-oxadiazoles mediated by (tosylimino)phenyl-γ3-iodane

A simple and convenient one-pot protocol for the synthesis of substituted 2-amino-1,3,4-oxadiazoles mediated by (tosylimino)phenyl-γ3- iodane has been described. Acylthiosemicarbazides prepared from the corresponding acylhydrazides undergo effi

Hypervalent iodine(V) mediated mild and convenient synthesis of substituted 2-amino-1,3,4-oxadiazoles

A simple protocol for the synthesis of 2-amino-1,3,4-oxadiazoles starting from the corresponding acylhydrazides by cyclodesulfurization of intermediate acylthiosemicarbazides mediated by o-iodoxybenzoic acid in good yields has been described. The protocol

Desulfurization strategy in the construction of azoles possessing additional nitrogen, oxygen or sulfur using a copper(I) catalyst

A tandem and convergent approach to various N-, O-, or S-containing azoles has been developed by exploiting the thiophilic property of copper( I) iodide used in a catalytic quantity. The present protocol gives access to amino-substituted tetrazoles, triazoles, oxadiazoles and thiadiazoles via oxidative desulfurization of their respective precursors followed by inter- or intramolecular attack of suitable nucleophiles. For aminotetrazoles and triazoles an excellent regioselectivity has been achieved through proper tuning of the pKa values of the parent amines attached to unsymmetrical thioureas. The method represents an autocatalytic process in which copper( I) iodide gets converted to copper(II) sulfide which in turn transforms to active copper(II) oxide that effectively carries forward the catalytic cycle. The fate of the copper catalyst has also been studied using scanning electron microscopic (SEM) and energy-dispersive X-ray spectroscopic (EDS) analyses which give an insight into the mechanism for this catalytic process.