26135-47-7Relevant academic research and scientific papers
Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor
Song, Eun Young,Kaur, Navneet,Park, Mi-Young,Jin, Yinglan,Lee, Kyeong,Kim, Guncheol,Lee, Ki Youn,Yang, Jee Sun,Shin, Jae Hong,Nam, Ky-Youb,No, Kyoung Tai,Han, Gyoonhee
, p. 1519 - 1524 (2008/09/21)
A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.
N-heterocyclic ureas as immune regulants
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, (2008/06/13)
Benzimidazolyl, benzothiazolyl and benzoxazolyl ureas and thioureas are employed as immune regulatory agents, as agents capable of altering the immune response in mammals.
