261359-07-3

Basic information

• Product Name: 1-trimethylsilyl-3(E)-decen-1-yn-5-one
• Synonyms: 1-trimethylsilyl-3(E)-decen-1-yn-5-one
• CAS NO: 261359-07-3
• Molecular Weight: 222.403
• Mol File: 261359-07-3.mol

Chemical Properties

• CAS DataBase Reference: 1-trimethylsilyl-3(E)-decen-1-yn-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-trimethylsilyl-3(E)-decen-1-yn-5-one(261359-07-3)
• EPA Substance Registry System: 1-trimethylsilyl-3(E)-decen-1-yn-5-one(261359-07-3)

Safety Data

• Hazardous Substances Data: 261359-07-3(Hazardous Substances Data)

Upstream product

• 41309-43-7 (2-bromovinyl)trimethylsilane 
• 142-61-0 Hexanoyl chloride 
• 1066-54-2 trimethylsilylacetylene 

Relevant articles and documents

Novel synthetic approach to (S)-coriolic acid

A new synthetic approach to (S)-coriolic acid 1 has been developed, starting from the readily available (E)-1-bromo-2-trimethylsilylethene 4 and trimethylsilylacetylene 5. A simple acylation reaction of 4, followed by a coupling reaction of the halogenoderivative intermediate with 5 in the presence of a Pd(0) catalyst affords the monosilylated ketoenyne 7. After desilylation of 7, enantioselective reduction of the carbonyl group with (S)- BINAL-H leads to the alcohol 2 (e.e.=94%). A subsequent coupling reaction and stereoselective reduction of the triple bond affords the target molecule 1.