261363-00-2

Basic information

• Product Name: Isonicotinic acid [1-amino-2-(4-chloro-phenoxy)-eth-(E)-ylidene]-hydrazide
• Synonyms: Isonicotinic acid [1-amino-2-(4-chloro-phenoxy)-eth-(E)-ylidene]-hydrazide
• CAS NO: 261363-00-2
• Molecular Weight: 304.736
• Mol File: 261363-00-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Isonicotinic acid [1-amino-2-(4-chloro-phenoxy)-eth-(E)-ylidene]-hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Isonicotinic acid [1-amino-2-(4-chloro-phenoxy)-eth-(E)-ylidene]-hydrazide(261363-00-2)
• EPA Substance Registry System: Isonicotinic acid [1-amino-2-(4-chloro-phenoxy)-eth-(E)-ylidene]-hydrazide(261363-00-2)

Safety Data

• Hazardous Substances Data: 261363-00-2(Hazardous Substances Data)

Upstream product

• 54-85-3 isoniazid 
• 3598-13-8 (4-chlorophenoxy)acetonitrile 

Relevant articles and documents

Synthesis and antimycobacterial activity of some isonicotinoylhydrazones

A series of isonicotinoylhydrazones 2 were prepared by addition of some aryloxyacetonitriles with isonicotinoylhydrazine in basic medium. These compounds have been further reacted with pyridinecarboxaldehydes to give the corresponding pyridylmethyleneamino derivatives 3-5. The new synthesized hydrazones and their pyridylmethyleneamino derivatives were tested for their activity against mycobacteria, Gram-positive and Gram-negative bacteria. The cytotoxicity was also tested. Several compounds showed a good activity against Mycobacterium tuberculosis H37Rv and some isonycotinoylhydrazones 2 showed a moderate activity against a clinically isolated M. tuberculosis which was isoniazid resistant.