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3-Hydroxy-5-methyl-benzoic acid methyl ester, also known as methyl 3-hydroxy-5-methylbenzoate, is a chemical compound characterized by the molecular formula C9H10O3. It is a white to off-white crystalline solid that is recognized for its sweet, pleasant odor. 3-Hydroxy-5-methyl-benzoic acid methyl ester is derived from benzoic acid and features a hydroxyl group and a methyl group attached to a benzene ring, which contributes to its unique properties. Being soluble in organic solvents, it is a versatile ingredient in various industries, though it requires careful handling to prevent potential irritation to the skin, eyes, and respiratory system.

2615-71-6

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2615-71-6 Usage

Uses

Used in the Food Industry:
3-Hydroxy-5-methyl-benzoic acid methyl ester is used as a flavoring agent for its ability to impart a sweet and pleasant taste to food products, enhancing their overall flavor profile.
Used in the Perfume Industry:
In the realm of perfumery, 3-Hydroxy-5-methyl-benzoic acid methyl ester serves as a valuable component due to its sweet, pleasant odor, contributing to the creation of various fragrances.
Used in the Pharmaceutical Industry:
3-Hydroxy-5-methyl-benzoic acid methyl ester is utilized in the production of pharmaceuticals, capitalizing on its chemical properties to formulate medications and improve their efficacy or palatability.
Used in Chemical Synthesis:
3-Hydroxy-5-methyl-benzoic acid methyl ester is also employed as an intermediate in the synthesis of other organic compounds, highlighting its versatility in chemical processes and the potential for further applications in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 2615-71-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,1 and 5 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2615-71:
(6*2)+(5*6)+(4*1)+(3*5)+(2*7)+(1*1)=76
76 % 10 = 6
So 2615-71-6 is a valid CAS Registry Number.

2615-71-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 3-hydroxy-5-methylbenzoate

1.2 Other means of identification

Product number -
Other names 5-Hydroxy-3-methyl-benzoesaeure-methylester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2615-71-6 SDS

2615-71-6Relevant articles and documents

WDR5 INHIBITORS AND MODULATORS

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Paragraph 0382; 0585, (2020/04/24)

Described are imino-azacycle-benzamide compounds compounds that inhibit WDR5 and associated protein-protein interactions, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and c

Sulfoximine-Assisted One-Pot Unsymmetrical Multiple Annulation of Arenes: A Combined Experimental and Computational Study

Ghosh, Koushik,Shankar, Majji,Rit, Raja K.,Dubey, Gurudutt,Bharatam, Prasad V.,Sahoo, Akhila K.

supporting information, p. 9667 - 9681 (2018/09/18)

Discussed herein is an unprecedented Ru-catalyzed one-pot unsymmetrical C-H difunctionalization of arenes comprising intramolecular hydroarylation of olefins and intermolecular annulation of alkynes. This unprecedented 2-fold C-H functionalization is validated on the basis of experimental and density functional theory (DFT) study. The transformation readily occurs with the assistance of methylphenyl sulfoximine (MPS) directing group in the presence of Ru catalyst forming two C-C and one C-N bonds in a single operation. The overall process is atom economical and step-efficient and provides unusual dihydrofuran-fused isoquinolone heterocycles. Further annulation of NH and the proximal o-C-H-arene of isoquinolone with alkynes build highly conjugated novel polycyclic compounds. Overall, three independent annulations in arene motifs are visualized and thoughtfully executed; finally, 5 ring-fused structural entities are constructed forming three C-C and two C-N bonds.

Synthesis of Phenols: Organophotoredox/Nickel Dual Catalytic Hydroxylation of Aryl Halides with Water

Yang, Liu,Huang, Zhiyan,Li, Gang,Zhang, Wei,Cao, Rui,Wang, Chao,Xiao, Jianliang,Xue, Dong

supporting information, p. 1968 - 1972 (2018/02/06)

A highly effective hydroxylation reaction of aryl halides with water under synergistic organophotoredox and nickel catalysis is reported. The OH group of the resulting phenols originates from water, following deprotonation facilitated by an intramolecular base group on the ligand. Significantly, aryl bromides as well as less reactive aryl chlorides served as effective substrates to afford phenols with a wide range of functional groups. Without the need for a strong inorganic base or an expensive noble-metal catalyst, this process can be applied to the efficient preparation of diverse phenols and enables the hydroxylation of multifunctional pharmaceutically relevant aryl halides.

Compound and application thereof

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Paragraph 0728; 0729, (2016/10/09)

The invention discloses a compound and application thereof. The compound is the compound shown in the formula (I) or a stereoisomer or a pharmaceutical acceptable salt or solvate or a prodrug of the compound shown in the formula (I). The compound can restrain tumor cell proliferation through the effect RRM2, and restrain tumor stem cell regeneration, thereby being effectively used for preparing medicine for preventing or treating proliferative diseases and particularly anti-cancer medicine.

Synthesis, structure-activity relationships, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics

Yang, Feipu,Jiang, Xiangrui,Li, Jianfeng,Wang, Yu,Liu, Yongjian,Bi, Minghao,Wu, Chunhui,Zhao, Qingjie,Chen, Weiming,Yin, Jingjing,Zhang, Jian,Xie, Yuanchao,Hu, Tianwen,Xu, Mingshuo,Guo, Shuang,Wang, Zhen,He, Yang,Shen, Jingshan

supporting information, p. 3141 - 3147 (2016/06/13)

In the present study, a series of benzamides, endowed with potent dopamine D2, serotonin 5-HT1A and 5-HT2A receptors properties, was synthesized and evaluated as potential antipsychotics. Among them, 3-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl)butoxy)-N-methylbenzamide (21) and its fluoro-substituted analogue (22) held the best pharmacological binding profiles. They not only presented potent activities for D2, 5-HT1A, and 5-HT2A receptors, but were also endowed with low activities for 5-HT2C, H1 receptors and hERG channels, suggesting a low propensity of inducing weight gain and QT prolongation. In animal models, compounds 21 and 22 reduced phencyclidine-induced hyperactivity with a high threshold for catalepsy induction. It thus provides potential candidates for further preclinical studies.

DERIVATIVES OF 1 H-PYRAZOLO[3,4-B]PYRIDINE AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

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Paragraph 00281; 00355, (2015/03/13)

The present invention discloses compounds according to Formula (I): wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds,methods for their production, pharmaceutical

NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

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Paragraph 0549; 0550; 0670, (2015/03/28)

The present invention discloses compounds according to Formula I: wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical

Total synthesis of jadomycins B, S, T, and ILEVS1080

Yang, Xiaoyu,Yu, Biao

supporting information, p. 8431 - 8434 (2013/07/19)

Sweetening up jadomycin A: The first total synthesis of jadomycins B, S, T, and ILEVS1080 has been achieved, featuring construction of the unique 8H-benz[b]oxazolo[3,3-f]phenanthridine skeleton by biomimetic condensation of a quinone aldehyde with amino acid sodium salts and elaboration of the glycosides by Mitsunobu condensation (see figure). Copyright

Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors

Isaacs, Richard C.A.,Newton, Christina L.,Cutrona, Kellie J.,Mercer, Swati P.,Payne, Linda S.,Stauffer, Kenneth J.,Williams, Peter D.,Cook, Jacquelynn J.,Krueger, Julie A.,Lewis, S. Dale,Lucas, Bobby J.,Lyle, Elizabeth A.,Lynch, Joseph J.,McMasters, Daniel R.,Naylor-Olsen, Adel M.,Michener, Maria T.,Wallace, Audrey A.

scheme or table, p. 1536 - 1540 (2011/04/23)

A novel 1,3,5-trisubstituted benzamide thrombin inhibitor template was designed via hybridization of a known aminopyridinoneacetamide and a known 1,3,5-trisubstituted phenyl ether. Optimization of this lead afforded a novel potent series of biaryl 1,3,5-trisubstituted benzenes with excellent functional anticoagulant potency.

THIAZOLE AND OXAZOLE KINASE INHIBITORS

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Page/Page column 136-137, (2009/04/25)

The present invention provides thiazole and oxazole compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

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