26151-87-1

Upstream product

• 5397-03-5 hydrazinecarbodithioic acid methyl ester 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 1228182-22-6 C₁₅H₁₃IN₄O₂S 
• 40971-04-8 1-(4-nitro-phenyl)-ethanone 4-(4-bromo-phenyl)-thiosemicarbazone 
• 40970-97-6 1-(4-nitro-phenyl)-ethanone 4-m-tolyl-thiosemicarbazone 
• 1228182-20-4 C₁₅H₁₂Cl₂N₄O₂S 
• 40971-08-2 1-(4-nitro-phenyl)-ethanone 4-(4-methoxy-phenyl)-thiosemicarbazone 
• 479513-01-4 C₁₅H₁₃FN₄O₂S 
• 1228182-21-5 C₁₅H₁₅N₅O₂S 

Relevant academic research and scientific papers

Substituted hydrazinecarbothioamide as potent antitubercular agents: Synthesis and quantitative structure-activity relationship (QSAR)

A series of novel substituted hydrazinecarbothioamides was synthesized and evaluated for anti-TB activity. Three most active compounds viz. 1, 6 and 12 were found to exhibit minimum inhibitory concentration (MIC) of 0.4 μg/mL, whereas four compounds viz. 3, 5, 10 and 11 showed comparatively lesser activity with MIC value of 0.8 μg/mL against Mycobacterium tuberculosis strain. A highly significant QSAR equation explaining 81.8% variance is described.

Synthesis and anticancer activity of thiosemicarbazones

Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC 50 of compound III-16 against SGC-7901 reaches to 0.032 μM.