479513-01-4Relevant academic research and scientific papers
Substituted hydrazinecarbothioamide as potent antitubercular agents: Synthesis and quantitative structure-activity relationship (QSAR)
Singh, Supriya,Mandal, Pintu K.,Singh, Nagendra,Misra, Anup K.,Singh, Shubhra,Chaturvedi, Vinita,Sinha, Sudhir,Saxena, Anil K.
scheme or table, p. 2597 - 2600 (2010/07/13)
A series of novel substituted hydrazinecarbothioamides was synthesized and evaluated for anti-TB activity. Three most active compounds viz. 1, 6 and 12 were found to exhibit minimum inhibitory concentration (MIC) of 0.4 μg/mL, whereas four compounds viz. 3, 5, 10 and 11 showed comparatively lesser activity with MIC value of 0.8 μg/mL against Mycobacterium tuberculosis strain. A highly significant QSAR equation explaining 81.8% variance is described.
