261525-11-5

Basic information

• Product Name: 1,2-O-isopropylidene-3-O-allyl-5-O-triphenylmethyl-α-D-xylofuranoside
• Synonyms: 1,2-O-isopropylidene-3-O-allyl-5-O-triphenylmethyl-α-D-xylofuranoside
• CAS NO: 261525-11-5
• Molecular Weight: 472.581
• Mol File: 261525-11-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-O-isopropylidene-3-O-allyl-5-O-triphenylmethyl-α-D-xylofuranoside(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-O-isopropylidene-3-O-allyl-5-O-triphenylmethyl-α-D-xylofuranoside(261525-11-5)
• EPA Substance Registry System: 1,2-O-isopropylidene-3-O-allyl-5-O-triphenylmethyl-α-D-xylofuranoside(261525-11-5)

Safety Data

• Hazardous Substances Data: 261525-11-5(Hazardous Substances Data)

Upstream product

• 20590-53-8 1,2-O-isopropylidene-5-O-trityl-α-D-xylofuranose 
• 106-95-6 allyl bromide 

Downstream Products

• 261525-13-7 (3'S,4'R) 1,2-O-isopropylidene-3-O-(3'-methyl-azetidin-2'-on-4'-yl)-5-O-trityl-α-D-xylofuranose 
• 261525-15-9 (3'S,4'R) 1,2-O-isopropylidene-3-O-(3'-methyl-azetidin-2'-on-4'-yl)-5-O-tosyl-α-D-xylofuranose 
• 261525-12-6 1,2-O-isopropylidene-3-O-(prop-1'-enyl)-5-O-trityl-α-D-xylofuranose 

Relevant articles and documents

A Semi-Synthetic Glycoconjugate Vaccine Candidate for Carbapenem-Resistant Klebsiella pneumoniae

Hospital-acquired infections are an increasingly serious health concern. Infections caused by carpabenem-resistant Klebsiella pneumoniae (CR-Kp) are especially problematic, with a 50 % average survival rate. CR-Kp are isolated from patients with ever greater frequency, 7 % within the EU but 62 % in Greece. At a time when antibiotics are becoming less effective, no vaccines to protect from this severe bacterial infection exist. Herein, we describe the convergent [3+3] synthesis of the hexasaccharide repeating unit from its capsular polysaccharide and related sequences. Immunization with the synthetic hexasaccharide 1 glycoconjugate resulted in high titers of cross-reactive antibodies against CR-Kp CPS in mice and rabbits. Whole-cell ELISA was used to establish the surface staining of CR-Kp strains. The antibodies raised were found to promote phagocytosis. Thus, this semi-synthetic glycoconjugate is a lead for the development of a vaccine against a rapidly progressing, deadly bacterium.

Synthesis of 7-substituted 5-dethia-5-oxacephams via [2+2]cycloaddition of chlorosulfonyl isocyanate to sugar vinyl ethers

[2+2]Cycloaddition of chlorosulfonyl isocyanate (CSI) to (Z) prop-1′-enyl, (Z) and (E) 4′-trimethylsilyl-but-1′-enyl ethers of 1,2-O-isopropylidene-5-O-trityl-α-D-xylofuranose proceeds with high stereoselectivity to afford respective azetidin-2-ones. Subs