261615-01-4Relevant academic research and scientific papers
Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors
Dragovich, Peter S.,Zhou, Ru,Webber, Stephen E.,Prins, Thomas J.,Kwok, Annette K.,Okano, Koji,Fuhrman, Shella A.,Zalman, Leora S.,Maldonado, Fausto C.,Brown, Edward L.,Meador III, James W.,Patick, Amy K.,Ford, Clifford E.,Brothers, Mary A.,Binford, Susan L.,Matthews, David A.,Ferre, Rose Ann,Worland, Stephen T.
, p. 45 - 48 (2000)
Tripeptide-derived molecules incorporating C-terminal ketone electrophiles were evaluated as reversible inhibitors of the cysteine- containing human rhinovirus 3C protease (3CP). An optimized example of such compounds displayed potent 3CP inhibition activ
