26162-82-3Relevant academic research and scientific papers
N-Heterocyclic carbene (NHC)-catalysed atom economical construction of 2,3-disubstituted indoles
Harish, Battu,Subbireddy, Manyam,Suresh, Surisetti
, p. 3338 - 3341 (2017)
A novel organocatalytic approach, harnessing the unique reactivities of N-heterocyclic carbenes (NHCs), has been revealed for the construction of indoles. The NHC-catalysed atom economical synthesis of a wide range of 2-substituted indole-3-acetic acid derivatives is displayed. Strategic application of the developed method was demonstrated for a short synthesis of a cyclin-dependent kinase (CDK) inhibitor: paullone.
Access to [2,1]benzothiazine s,s-dioxides from β-substituted o-nitrostyrenes and sulfur
Mac, Dinh Hung,Nguyen, Thanh Binh,Nguyen, Thi Mo,Cao, Hoang Anh,Cao, Thi Thuong Thuong,Koyama, Satoki
, p. 12058 - 12066 (2020/11/10)
[2,1]Benzothiazine S,S-dioxides 2 were synthesized by simply heating o-nitrostyrenes with elemental sulfur in 3- picoline with complete atom economy. This reaction was found to occur without any added catalyst and consist of a cascade of reduction of the
