147375-18-6Relevant academic research and scientific papers
N-Heterocyclic-Carbene-Catalyzed Umpolung of Imines
Patra, Atanu,Mukherjee, Subrata,Das, Tamal Kanti,Jain, Shailja,Gonnade, Rajesh G.,Biju, Akkattu T.
, p. 2730 - 2734 (2017/02/26)
N-Heterocyclic carbene (NHC) catalysis has been widely used for the umpolung of aldehydes, and recently for the umpolung of Michael acceptors. Described herein is the umpolung of aldimines catalyzed by NHCs, and the reaction likely proceeds via aza-Breslo
Synthetic method 2-aryl indole-3-acetic acid derivatives using cyanide as a catalyst
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, (2017/10/20)
The present invention relates to a novel method for producing an indole-3-acetic acid derivative using cyanide as a catalyst. According to the present invention, the method for producing the indole-3-acetic acid derivative is simple, and ensures high reproducibility and safety.COPYRIGHT KIPO 2017
Synthetic method 2-aryl indole-3-acetic acid derivatives using cyanide as a catalyst
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, (2018/02/10)
The present invention relates to a novel method for producing an indole-3-acetic acid derivative represented by chemical formula 1 by using cyanide as a catalyst. The method comprises a step of making a compound represented by chemical formula 2 react with alkali metal cyanide. An indoe-3-acetic acid derivative which can be used as an intermediate body for producing various natural materials and medical products can be produced. The method is convenience, has high reproducibility, and is a safe reaction. Thus, the method can be usefully applied to an industrialization process requiring mass-production.COPYRIGHT KIPO 2017
N-Heterocyclic carbene (NHC)-catalysed atom economical construction of 2,3-disubstituted indoles
Harish, Battu,Subbireddy, Manyam,Suresh, Surisetti
, p. 3338 - 3341 (2017/03/22)
A novel organocatalytic approach, harnessing the unique reactivities of N-heterocyclic carbenes (NHCs), has been revealed for the construction of indoles. The NHC-catalysed atom economical synthesis of a wide range of 2-substituted indole-3-acetic acid derivatives is displayed. Strategic application of the developed method was demonstrated for a short synthesis of a cyclin-dependent kinase (CDK) inhibitor: paullone.
Synthesis of 2-Aryl-Substituted Indole-3-acetic Acid Derivatives via Intramolecular Imino-Stetter Reaction of Aldimines with Cyanide
Lee, Seong Jong,Seo, Hong-Ahn,Cheon, Cheol-Hong
, p. 1566 - 1570 (2016/10/13)
A general method to generate umpolung of aldimines with cyanide was developed via the addition of cyanide to aldimines followed by a proton transfer from the carbon atom to the nitrogen atom in the resulting cyanide adducts. This novel method was successf
Preparation of indoles from α-aminonitriles: A short synthesis of FGIN-1-27
Opatz, Till,Ferenc, Dorota
, p. 4473 - 4475 (2007/10/03)
α-Aminonitriles derived from 2-aminocinnamic acid esters and amides can be cyclized under basic conditions to furnish substituted indole-3-acetic acid derivatives in quantitative yield. The reaction provides a simple access to a class of biologically acti
Chemistry, Binding Affinities, and Behavioral Properties of a New Class of "Antineophobic" Mitochondrial DBI Receptor Complex (mDRC) Ligands
Kozikowski, A. P.,Ma, D.,Brewer, James,Sun, S.,Costa, E.,et al.
, p. 2908 - 2920 (2007/10/02)
The mitochondrial DBI receptor complex (mDRC; previously called the peripheral benzodiazepine receptors) is linked to the production of neurosteroids such as pregnenolone sulfate, dehydroepiandrosterone sulfate, and others.In order to gain further informa
