261709-46-0

Upstream product

• 261711-70-0 5-tert-butyl-6-thiocyanato-benzothiazol-2-yl-amine 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 1950-69-2 toluene-p-sulfonyl bromide 
• 261709-31-3 2-amino-5-tert-butyl-benzothiazole-6-thiol 
• 5369-19-7 3-tert-butylaniline 
• 70729-05-4 1-Bromo-4-tert-butyl-2-nitro-benzene 

Downstream Products

• 261709-66-4 Toluene-4-thiosulfonic acid S-(2-acetylamino-5-tert-butyl-benzothiazol-6-yl)ester 

Relevant academic research and scientific papers

HIV protease inhibitors

The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

Thiocyanation of alkylanilines. A simple and efficient synthesis of thiosulfonates containing 2-aminobenzothiazole

Thiocyanation of anilines was used to introduce a thiol functionality and to construct the aminothiazole ring, all in a single step. A systematic study of thiocyanation of alkyl anilines was investigated to understand the regio-chemistry of the reaction. X-Ray crystal structures of two 2- aminobenzothiazoles were determined to assign the structures without any ambiguity. The intermediates obtained were further expanded to thiosulfonates containing 2-aminobenzothiazoles, which are extremely valuable intermediates to synthesize HIV protease inhibitors. (C) 2000 Elsevier Science Ltd.