26171-90-4

Basic information

• Product Name: Dinaphtho[2,3-b:2',3'-d]furan-5,7,12,13-tetrone
• Synonyms: Dinaphtho[2,3-b:2',3'-d]furan-5,7,12,13-tetrone
• CAS NO: 26171-90-4
• Molecular Formula: C20H8O5
• Molecular Weight: 328.27
• Mol File: 26171-90-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 347 °C (decomp)
• Boiling Point: 588.2±49.0 °C(Predicted)
• Appearance: /
• Density: 1.552±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Dinaphtho[2,3-b:2',3'-d]furan-5,7,12,13-tetrone(CAS DataBase Reference)
• NIST Chemistry Reference: Dinaphtho[2,3-b:2',3'-d]furan-5,7,12,13-tetrone(26171-90-4)
• EPA Substance Registry System: Dinaphtho[2,3-b:2',3'-d]furan-5,7,12,13-tetrone(26171-90-4)

Safety Data

• Hazardous Substances Data: 26171-90-4(Hazardous Substances Data)

Upstream product

• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 
• 405264-19-9 3'-chloro-3-hydroxy-2,2'-binaphthalenyl-1,4,1',4'-tetraone 
• 33440-64-1 2,2'-bis(3-hydroxy-1,4-naphthoquinone) 
• 70502-14-6 3,3'-dimethoxy[2,2'-binaphthalene]-1,1',4,4'-tetrone 
• 3408-13-7 2,2'-binaphthoquinone 
• 127611-78-3 3-Hydroxy-3'-piperidino-2,2'-binaphthyl-1,4;1',4'-dichinon 
• 108-24-7 acetic anhydride 
• 129230-61-1 1,1',3,3',4,4'-hexamethoxy-2,2'-binaphthalene 

Relevant articles and documents

Advance of Seriniquinone Analogues as Melanoma Agents

Seriniquinone, a marine natural product, displayed potent cytotoxicity and selectivity against melanoma cancer cells. This selectivity, combined with a novel mode of action (MOA), prompted studies to translate a pharmacologically relevant lead. Herein, we report on structure-activity relationships (SARs), and provide a strategy to prepare analogues that retain activity and offer an improved water solubility and isomeric purity. From intermediates made on a gram-scale, derivatives were prepared and evaluated for their antiproliferation activity and melanoma selectivity. Overall these studies provide methods to install side chain motifs that demonstrate a common, and yet unique, biological profile.

Methylation of 3,3'-Dihydroxylated 2,2'-Binaphtho-1,4;1',4'-quinones

Monomeric hydroxy-p-quinones (1) are in equilibrium with the corresponding o-quinones (2) and on methylation, a mixture of both isomeric ethers is obtained.In contrast, dimeric hydroxynaphthoquinones with 3a-skeleton in treatment with diazomethane are yie