84194-30-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-5-fluorobenzaldehyde is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-5-fluorobenzaldehyde serves as a key intermediate in the production of agrochemicals. Its incorporation into these compounds can enhance their effectiveness in pest control and crop protection, thereby supporting agricultural productivity.
Used in Dye and Perfume Industry:
2-Chloro-5-fluorobenzaldehyde is employed in the dye and perfume industry for the production of various dyes and fragrances. Its aromatic properties make it a valuable component in creating a wide range of colorants and scents used in different applications.
Used in Organic Chemical Reactions:
As a building block in organic chemistry, 2-Chloro-5-fluorobenzaldehyde is used for the preparation of other compounds. Its reactivity and structural features enable the synthesis of a variety of organic molecules, expanding the scope of chemical research and development.

InChI:InChI=1/C7H4ClFO/c8-7-2-1-6(9)3-5(7)4-10/h1-4H

Upstream product

• 81778-09-8 1-(bromomethyl)-2-chloro-5-fluorobenzene 
• 2252-50-8 2-chloro-5-fluoro-benzoic acid 
• 261762-59-8 (2-chloro-5-fluorophenyl)methanol 
• 33406-96-1 2-chloro-5-fluorotoluene 

Downstream Products

• 84194-31-0 trans-3-(2-chloro-5-fluorostyryl)phenanthrene 
• 1292850-25-9 N-{4-chloro-2-[(2-chloro-5-fluorophenyl)(hydroxy)-methyl]phenyl}-2,2-dimethylpropanamide 
• 1292850-26-0 {5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chloro-5-fluorophenyl)methanol 
• 1223405-13-7 (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine 
• 261762-59-8 (2-chloro-5-fluorophenyl)methanol 
• 917391-36-7 tert-butyl [3-[(2-chloro-5-fluoro-phenyl)methylamino]-6-methyl-2-oxo-4-thioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetic acid 
• 917391-33-4 tert-butyl [3-[2-chloro-5-fluoro-benzylamino]-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate 

Relevant academic research and scientific papers

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors

To obtain small and efficient squalene synthase inhibitors, a flexible 2-aminobenzhydrol open form structure was designed and showed potent inhibitory activity comparable to 4,1-benzoxazepin compounds. Further chemical modification led to the discovery of a novel template with a strong squalene synthase inhibitory activity, and its basic structure-activity relationship was revealed. The X-ray crystallographic data of compound 12 bound to the active site of squalene synthase provided an important insight into the binding mode of this alternative template that formed 11-membered ring conformations with an intramolecular hydrogen bond.

PERNASAL PREPARATIONS

A nasal preparation comprising a compound represented by the formula: wherein Ring A is an optionally substituted 5- or 6-membered aromatic heterocyclic ring, Ring B is an optionally substituted 5- or 6-membered aromatic homocyclic or heterocyclic ring, R

Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof

The present invention is to provide a compound of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic heterocyclic ring, the ring B an optionally substituted 5- to 6-membered aromatic homocyclic ring or an optionally sub

An Unusual Fluorine Atom Rearrangement in the Photocyclization of 1-Fluorohelicenes

Oxidative photocyclization of 1-fluorohelicene and two of its chlorine-substituted derivatives leads to the formation of 8-fluorobenzoperylenes through an unprecedented inter-ring fluorine atom migration; photoelimination of HF to give benzoperylenes also occurs as a competing process.The rearrangement pathway predominates when the irradiation is carried out at 0 deg C in air-saturated benzene solution containing 10 -3 M iodine; the elimination pathway predominates at higher temperatures or in the absence of either oxygen or iodine.The rearrangement isrationalized by postulating a triplet-state photocyclization to give a dihydrobenzoperylene intermediate, followed by abstraction of the tertiary hydrogen atom from that intermediate to give a radical that subsequently undergoes a fluorine atom shift by an SNi'mechanism.