84194-30-9

Basic information

• Product Name: 2-Chloro-5-fluorobenzaldehyde
• Synonyms: 2-CHLORO-5-FLUOROBENZALDEHYDE;2-Chloro-5-Flourobenzaldehyde;Benzaldehyde, 2-chloro-5-fluoro-
• CAS NO: 84194-30-9
• Molecular Formula: C₇H₄ClFO
• Molecular Weight: 158.56
• Product Categories: Fluorin-contained benzaldehyde series;Carbonyl Compounds;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Fluorobenzene;Fluorine series
• Mol File: 84194-30-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 46.5-48°C
• Boiling Point: 207.2 °C at 760 mmHg
• Flash Point: 79.1 °C
• Appearance: /
• Density: 1.352 g/cm³
• Vapor Pressure: 0.228mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Chloro-5-fluorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-fluorobenzaldehyde(84194-30-9)
• EPA Substance Registry System: 2-Chloro-5-fluorobenzaldehyde(84194-30-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 84194-30-9(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-fluorobenzaldehyde is a chemical compound with the molecular formula C7H4ClFO. It is a derivative of benzaldehyde, with chlorine and fluorine atoms substituted at the 2 and 5 positions of the benzene ring, respectively. 2-Chloro-5-fluorobenzaldehyde is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and perfumes. It is also utilized in organic chemical reactions as a building block for the preparation of various other compounds. 2-Chloro-5-fluorobenzaldehyde is a clear, colorless liquid with a strong, aromatic odor, and it is important to handle it with appropriate safety precautions due to its potential toxicity and irritant properties.

InChI:InChI=1/C7H4ClFO/c8-7-2-1-6(9)3-5(7)4-10/h1-4H

Upstream product

• 2252-50-8 2-chloro-5-fluoro-benzoic acid 
• 261762-59-8 (2-chloro-5-fluorophenyl)methanol 
• 33406-96-1 2-chloro-5-fluorotoluene 
• 81778-09-8 1-(bromomethyl)-2-chloro-5-fluorobenzene 

Downstream Products

• 1292850-25-9 N-{4-chloro-2-[(2-chloro-5-fluorophenyl)(hydroxy)-methyl]phenyl}-2,2-dimethylpropanamide 
• 1292850-26-0 {5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chloro-5-fluorophenyl)methanol 
• 1223405-13-7 (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine 
• 261762-59-8 (2-chloro-5-fluorophenyl)methanol 
• 917391-36-7 tert-butyl [3-[(2-chloro-5-fluoro-phenyl)methylamino]-6-methyl-2-oxo-4-thioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetic acid 
• 917391-33-4 tert-butyl [3-[2-chloro-5-fluoro-benzylamino]-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]acetate 

Relevant articles and documents

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors

To obtain small and efficient squalene synthase inhibitors, a flexible 2-aminobenzhydrol open form structure was designed and showed potent inhibitory activity comparable to 4,1-benzoxazepin compounds. Further chemical modification led to the discovery of a novel template with a strong squalene synthase inhibitory activity, and its basic structure-activity relationship was revealed. The X-ray crystallographic data of compound 12 bound to the active site of squalene synthase provided an important insight into the binding mode of this alternative template that formed 11-membered ring conformations with an intramolecular hydrogen bond.

Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof

The present invention is to provide a compound of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic heterocyclic ring, the ring B an optionally substituted 5- to 6-membered aromatic homocyclic ring or an optionally sub

An Unusual Fluorine Atom Rearrangement in the Photocyclization of 1-Fluorohelicenes

Oxidative photocyclization of 1-fluorohelicene and two of its chlorine-substituted derivatives leads to the formation of 8-fluorobenzoperylenes through an unprecedented inter-ring fluorine atom migration; photoelimination of HF to give benzoperylenes also occurs as a competing process.The rearrangement pathway predominates when the irradiation is carried out at 0 deg C in air-saturated benzene solution containing 10 -3 M iodine; the elimination pathway predominates at higher temperatures or in the absence of either oxygen or iodine.The rearrangement isrationalized by postulating a triplet-state photocyclization to give a dihydrobenzoperylene intermediate, followed by abstraction of the tertiary hydrogen atom from that intermediate to give a radical that subsequently undergoes a fluorine atom shift by an SNi'mechanism.