261925-88-6

Usage

Uses

Used in Pharmaceutical Development:
Tert-butyl 4-[3-(hydroxymethyl)phenyl]piperazine-1-carboxylate is used as a chemical intermediate in the synthesis of new pharmaceuticals for [application reason]. Its unique structure, including the tert-butyl and hydroxymethyl groups, may offer specific binding or reactivity profiles that are advantageous in the creation of therapeutic agents.
Used in Drug Delivery Systems:
In the field of drug delivery, tert-butyl 4-[3-(hydroxymethyl)phenyl]piperazine-1-carboxylate is used as a component in the design of advanced drug delivery systems for [application reason]. tert-butyl 4-[3-(hydroxymethyl)phenyl]piperazine-1-carboxylate's structural features may facilitate targeted drug delivery, enhance bioavailability, or improve the stability and release profile of therapeutic agents.
Used in Medicinal Chemistry Research:
Tert-butyl 4-[3-(hydroxymethyl)phenyl]piperazine-1-carboxylate serves as a subject of study in medicinal chemistry research for [application reason]. Its synthesis and modification can provide insights into the development of new drug candidates, potentially leading to the discovery of compounds with improved pharmacological properties.

InChI:InChI=1/C16H24N2O3/c1-16(2,3)21-15(20)18-9-7-17(8-10-18)14-6-4-5-13(11-14)12-19/h4-6,11,19H,7-10,12H2,1-3H3

Upstream product

• 1257849-25-4 4-(3-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 261925-94-4 tert-butyl 4-(3-(ethoxycarbonyl)-phenyl)piperazine-1-carboxylate 
• 179003-10-2 tert-butyl 4-(3-(methoxycarbonyl)phenyl)-piperazine-1-carboxylate 
• 618-89-3 methyl 3-bromobenzoate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 795264-41-4 (3-piperazin-1-yl-phenyl)-methanol 
• 756753-27-2 [3-(piperazin-1-yl)phenyl]methanol hydrochloride 
• 1037078-97-9 4-(3-methanesulfonyloxymethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region

Pyroglutamate-modified amyloid β peptides (pGlu-Aβ) are highly neurotoxic and promote the formation of amyloid plaques. The pGlu-Aβ peptides are generated by glutaminyl cyclase (QC), and recent clinical studies indicate that QC represents an alternative t

OXABOROLE ESTERS AND USES THEREOF

The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.

TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE

The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS

The present invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

LIGANDS FOR IMAGING CARDIAC INNERVATION

Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side

NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME

The present invention relates to novel chromene or thiochromene carboxamide derivatives, the preparation of same, pharmaceutical compositions of same and the use of same as dopamine D3 ligands as a medicament for central nervous system disorders.