26195-65-3 Usage
Uses
Used in Pharmaceutical Industry:
N-[(S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-2,2,2-trifluoroacetamide is used as an antimitotic agent for its ability to disrupt microtubules by binding to tubulin and preventing its polymerization. This action stimulates the intrinsic GTPase activity of tubulin, leading to the induction of apoptosis in several normal and tumor cell lines. Additionally, it activates the JNK/SAPK signaling pathway, which plays a crucial role in cell survival and apoptosis regulation.
Used in Chemical Research:
In the field of chemical research, N-[(S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-2,2,2-trifluoroacetamide can be utilized as a starting material or intermediate for the synthesis of other complex organic compounds. Its unique structure and properties make it a valuable tool for exploring new chemical reactions and developing novel molecules with potential applications in various industries.
Used in Drug Delivery Systems:
Similar to gallotannin, N-[(S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-2,2,2-trifluoroacetamide may also be employed in the development of drug delivery systems to enhance its bioavailability and therapeutic outcomes. By incorporating N-[(S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-2,2,2-trifluoroacetamide into various organic and metallic nanoparticles, researchers can improve its delivery to target cells and tissues, potentially increasing its efficacy in treating specific conditions or diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 26195-65-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,1,9 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 26195-65:
(7*2)+(6*6)+(5*1)+(4*9)+(3*5)+(2*6)+(1*5)=123
123 % 10 = 3
So 26195-65-3 is a valid CAS Registry Number.
InChI:InChI=1/C22H22F3NO6/c1-29-16-8-6-12-13(10-15(16)27)14(26-21(28)22(23,24)25)7-5-11-9-17(30-2)19(31-3)20(32-4)18(11)12/h6,8-10,14H,5,7H2,1-4H3,(H,26,28)/t14-/m0/s1
26195-65-3Relevant academic research and scientific papers
Quantitative Structure-Activity Relationships of Colchicines against P388 Leukemia in Mice
Quinn, Frank R.,Beisler, John A.
, p. 251 - 256 (2007/10/02)
A quantitative structure-activity relationship (QSAR) was derived for colchicine and 14 analogues acting against P388 lymphocytic leukemia in mice.Twelve additional compounds were synthesized to reinforce and confirm the correlation.The final correlation
