261963-32-0

Upstream product

• 15890-00-3 dimethyl β-oxopimelate 
• 171561-59-4 (-)-5-oxo-6-[(R)-(phenyl)(phenylmethoxycarbonylamino)acetoxy]hexanoic acid methyl ester 
• 76700-85-1 6-Chlor-5-oxo-hexancarbonsaeuremethylester 
• 171561-61-8 4-(6-oxo-5R-phenyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)butanoic acid methyl ester 

Downstream Products

• 41373-39-1 (S)-pipecolinol 
• 171561-66-3 (-)-(2R)-[(2S)-(hydroxymethyl)piperidin-1-yl]-2-phenylethanol 
• 196937-35-6 (2S)-[(2-hydroxy-(1R)-phenyl)ethylamino]hexan-1,6-diol 
• 171561-64-1 (-)-(4R,9aS)-4-phenyltetrahydropyrido-[2,1-c][1,4]oxazin-3,6-dione 

Relevant academic research and scientific papers

A general synthesis of enantiopure 1,2-aminoalcohols via chiral morpholinones

Eleven optically active 1,2-aminoalcohols 20a-i and 26b-c were prepared from D-phenylglycine via cyclic imines 7b-i (or enamine 7a). The key step of the strategy is the diastereoselective reduction of chiral oxazinones 7a-i.

Asymmetric synthesis with chiral hydrogenolysable amines : A new route to enantiomerically pure amino diols

Enantiomerically pure amino diols are obtained via diastereoselective reduction of chiral enamino and imino esters (3a), (3b), and (3c).

Asymmetric Synthesis with Chiral Hydrogenolysable Amines: A New Route to Enantiopure Cyclic β-Amino Alcohols

Enantiopure prolinol and pipecolinol have been obtained via diastereoselective chemical reduction of chiral 2,3-dihydro-6H-1,4-oxazin-2-ones (5).