261968-17-6

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 160666-92-2 (S)-2-benzoyloxypentan-3-one 
• 104701-87-3 (2S)-3-(tert-butyl-dimethyl-silyloxy)-2-methyl-propanal 
• 93454-85-4 (S)-3-(tert-butyldimethylsilyloxy)-2-methylpropionic acid methyl ester 
• 308240-89-3 (+)-(S)-N-Methoxy-N-methyl-3-tert-butyldimethylsilyloxy-2-methyl-propionamide 

Downstream Products

• 261968-18-7 (2S,4R,5R,6S)-2-benzoyloxy-7-(t-butyldimethylsilyloxy)-5-(p-methoxybenzyloxy)-4,6-dimethylheptan-3-one 
• 1187629-51-1 (2S,4R,5R,6S)-7-(tert-butyldimethylsilyloxy)-5-methoxy-4,6-dimethyl-3-oxoheptan-2-yl benzoate 
• 373645-71-7 (2S,3R,4S,5Z,8R,9S,10R,11S,12S,13Z)-1,11-bis-(p-methoxybenzyloxy)-8-[(2,4,6-trimethylphenyl)sulfonyloxymethyl]-2,4,6,10,12-pentamethyl-hexadeca-5,13,15-trien-3,9-diol 
• 373645-83-1 tert-Butyl-{(Z)-(1R,2S)-5-{(2R,3R)-2-[(Z)-(1R,2S,3S)-2-(4-methoxy-benzyloxy)-1,3-dimethyl-hepta-4,6-dienyl]-oxetan-3-yl}-1-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,4-dimethyl-pent-3-enyloxy}-dimethyl-silane 
• 373645-70-6 (5Z,13Z)-1,11-bis-(p-methoxybenzyloxy)-8-hydroxymethyl-2,4,6,10,12-pentamethyl-hexadeca-5,13,15-triene-3,9-diol 
• 373645-72-8 (2S,3R,4S,5Z,8S,9R,10S,11S,12S,13Z)-1,11-bis-(p-methoxybenzyloxy)-2,4,6,8,10,12-hexamethyl-hexadeca-5,13,15-triene-3,9-diol 
• 373645-66-0 (3Z,5S,6S,7R,8S,9R,11Z,13S,14R,15S)-14-(t-butyldimethylsilyloxy)-6,16-bis(p-methoxybenzyloxy)-9-[(2,4,6-trimethylphenyl)sulfoxymethyl]-5,7,11,13,15-pentamethyl-hexadeca-1,3,11-trien-8-ol 
• 261968-21-2 (2,6-dimethylphenyl) (2S,3S,4S,5S,6S,7Z)-2-[(2Z,4S,5R,6S)-5-(t-butyldimethylsilyloxy)-7-(p-methoxybenzyloxy)-2,4,6-trimethyl-hept-2-enyl]-3-hydroxy-5-(p-methoxybenzyloxy)-4,6-dimethyldeca-7,9-dienoate 
• 256920-81-7 1-[(5Z,13Z)-(2S,3R,4S,8S,9R,10R,11S,12S)-11-(4-methoxybenzoxy)-3,9-bis(tert-butyldimethylsilanyloxy)-2,4,6,8,10,12-hexamethylhexadeca-5,13,15-trienyloxymethyl]-4-methoxybenzene 
• 373645-65-9 (3Z,5S,6S,7S,8R,9R,11Z,13S,14R,15S)-14-(t-butyldimethylsilyloxy)-6,16-bis(p-methoxybenzyloxy)-9-(hydroxymethyl)-5,7,11,13,15-pentamethylhexadeca-1,3,11-trien-8-ol 
• 261968-22-3 (3Z,5S,6S,7S,8R,9S,11Z,13S,14R,15S)-14-(t-butyldimethylsilyloxy)-6,16-bis-(p-methoxybenzyloxy)-5,7,9,11,13,15-hexamethyl-hexadeca-1,3,11-trien-8-ol 
• 261968-19-8 [2S,4S,5R,6S]-7-(t-butyldimethylsilyloxy)-5-(p-methoxybenzyloxy)-4,6-dimethylheptan-2,3-diol 
• 261968-20-1 (-)-(2R,3R,4S)-5-(tert-butyldimethylsilanyloxy)-3-(4-methoxybenzyloxy)-2,4-dimethylpentanal 
• 184291-96-1 (+)-tert-butyl-[(Z)-(2S,3S,4S)-3-(4-methoxybenzyloxy)-2,4-dimethylocta-5,7-dienyloxy]dimethylsilane 

Relevant academic research and scientific papers

A practical synthesis of (+)-discodermolide and analogues: Fragment union by complex aldol reactions

A practical stereocontrolled synthesis of (+)-discodermolide (1) has been completed in 10.3% overall yield (23 steps longest linear sequence). The absolute stereochemistry of the C1-C6 (7), C9-C16 (8), and Csub

Relative stereochemical determination and synthesis of the C1-C17 fragment of a new natural polyketide

(Chemical Equation Presented) The challenging determination of the relative stereochemistry of a complex natural polyketide portion was achieved. After careful NMR analysis, a concise synthesis of a set of possible relative diastereomers (only 6 diastereo

Total synthesis of the antimicrotubule agent (+)-discodermolide using boron-mediated aldol reactions of chiral ketones

With a similar mechanism of action to taxol, the title compound 1 is a particularly promising candidate for development in cancer chemotherapy. This efficient synthesis, based on stereocontrolled aldol reactions, should help to overcome the scarce natural