26209-83-6

Usage

Uses

Used in Pharmaceutical Industry:
3-(METHYLSULFONYL)PROPAN-1-AMINE HYDROCHLORIDE is used as a pharmaceutical intermediate for the synthesis of various drugs and pharmaceuticals, contributing to the development of new treatments and medications.
Used in Research Laboratories:
In research settings, 3-(METHYLSULFONYL)PROPAN-1-AMINE HYDROCHLORIDE is employed as a key component in the development of innovative medicinal compounds, aiding in the advancement of medical science and healthcare solutions.
It is crucial to handle 3-(METHYLSULFONYL)PROPAN-1-AMINE HYDROCHLORIDE with care, adhering to proper safety protocols to mitigate its potential irritant and harmful properties.

InChI:InChI=1/C4H11NO2S.ClH/c1-8(6,7)4-2-3-5;/h2-5H2,1H3;1H

Upstream product

• 4104-45-4 3-methylthio-1-propanamine 
• 505-34-0 cheirolin 
• 7647-01-0 hydrogenchloride 
• 98184-58-8 2-<(3-Methylsulfonyl)propyl>-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 505-34-0 cheirolin 
• 75-75-2 methanesulfonic acid 
• 417716-61-1 N-(4-(6-Cyano-7-(2-methoxyethoxy)-4-quinolyl)oxyphenyl)-N'-(3-methylsulfonylpropyl)urea 
• 554458-50-3 4-(3-methylsulfonylpropylamino)-3-nitrobenzonitrile 

Relevant academic research and scientific papers

A kind of IDO inhibitor and use thereof

The embodiment of the invention provides general formula (I) compound or its pharmaceutically acceptable salts, stereoisomers, a tautomeric form each other, polymorphs, solvate, prodrug, metabolite or isotope derivatives, wherein the substituents R1

Synthesis of novel analogs of acetyl coenzyme A: Mimics of enzyme reaction intermediates

An improved method for the synthesis of analogs of coenzyme A (CoA) and its thioesters, which are modified in the thiol or thioester moiety, has been developed using a combination of chemical and enzymatic reactions. The enzymes catalyzing the last two steps of CoA biosynthesis were used to prepare a CoA analog (Ic) in which an amide bond is replaced by a thioester bond and the thiol group is replaced by a methyl group. Reaction of Ic with a primary amine in aqueous solution results in aminolysis of the thioester linkage to form the desired CoA analog. Reaction with different amines permits the introduction of a variety of functional groups in place of the normal thiol or thioester group. This methodology has been used in the synthesis of five new analogs of acetyl-CoA in which the thioester sulfur is replaced by a methylene group and the acetyl group is replaced by carboxylate (14a), nitro (14b), carboxamide (14c), methyl sulfoxide (14d), and methyl sulfone (14e) groups. 14a-c were designed to mimic the possible enolate or enol intermediate in the reaction of citrate synthase and related enzymes. 14a and 14c are potent inhibitors of citrate synthase, with K(i) values 1000- and 570-fold lower than the K(m) for acetyl-CoA, respectively. CD titrations indicate that 14a and 14c have low affinity for citrate synthase in the absence of oxaloacetate, consistent with their recognition as enol or enolate analogs. 14b is a poor inhibitor of citrate synthase, with affinity slightly lower than that for acetyl-CoA. These results are consistent with generation of the enol form of acetyl-CoA as the nucleophilic intermediate in the reaction of citrate synthase. 14d and 14e were designed to mimic the tetrahedral intermediate or transition state in the reaction of chloramphenicol acetyltransferase and related acetyl-CoA-dependent acetyltransferases. Both compounds are poor inhibitors of chloramphenicol acetyltransferase, with affinities slightly lower than that of acetyl-CoA, indicating that these compounds are not good mimics of the enzyme-bound tetrahedral intermediate or transition state.