262268-69-9Relevant academic research and scientific papers
Intramolecular carbocupration of N-aryl-ynamides: A modular indole synthesis
Gati, Wafa,Couty, Francois,Boubaker, Taoufik,Rammah, Mohamed M.,Rammah, Mohamed B.,Evano, Gwilherm
supporting information, p. 3122 - 3125 (2013/07/26)
A modular indole synthesis based on an intramolecular 5-endo-dig carbocupration starting from readily available N-aryl-ynamides is reported. A variety of ynamides are converted to indoles in moderate to good yields and with varying substitution pattern on the indole ring. This further extends the synthetic utility of ynamides in organic synthesis and provides additional insights on the use of intramolecular carbometalation reactions.
Palladium-catalyzed bromoalkynylation of C-C double bonds: Ring-structure-dependent synthesis of 7-alkynyl norbornanes and cyclobutenyl halides
Li, Yibiao,Liu, Xiaohang,Jiang, Huanfeng,Liu, Bifu,Chen, Zhengwang,Zhou, Peng
supporting information; experimental part, p. 6341 - 6345 (2011/09/13)
Strain versus flexibility: The palladium-catalyzed reaction of haloalkynes with norbornene derivatives leads to 7-alkynyl norbornane products (see scheme). Key to the success of this reaction is the formation of a "bridging" palladium species, which can rearrange to result in a C-7 functionalization. The ring-structure-dependent [2+2] cycloaddition of haloalkynes with cyclooctene has been achieved in moderate to good yields under similar conditions. Copyright
Highly efficient two-step synthesis of (Z)-2-halo-1-iodoalkenes from terminal alkynes
Chen, Zhengwang,Jiang, Huanfeng,Li, Yibiao,Qi, Chaorong
supporting information; experimental part, p. 8049 - 8051 (2011/01/03)
The easily accessible haloalkynes can be converted to (Z)-2-halo-1- iodoalkenes in high yields with excellent regio- and stereoselectivity. The method shows good functional group compatibility. The resulting products could find broad applications.
Phenyl β-methoxyacrylates: A new antimalarial pharmacophore
Alzeer, Jawad,Chollet, Jacques,Heinze-Krauss, Ingrid,Hubschwerlen, Christian,Matile, Hugues,Ridley, Robert G.
, p. 560 - 568 (2007/10/03)
Phenyl β-methoxyacrylates, linked to an aromatic ring via an olefinic bridge, have been identified as novel, potentially inexpensive, antimalarial agents. The compounds are believed to exert their activity by inhibition of mitochondrial electron transport
Synthesis and Non-Linear Optical Properties of Diacetylenes with Conjugated Side Groups
Wright, J.,Milburn, G. H. W.,Shand, A. J.,Werninck, A. R.,Coles, H. J.,Smith, D. A. McL
, p. 1 - 14 (2007/10/02)
Seven novel diacetylenes have been synthesised, with six of these containing a pyridine ring directly conjugated to the main diacetylene unit.Values of χ2 and χ3 for these diacetylenes as guests in a guest-host polymer matrix (polysi
