704-41-6

Usage

Uses

Used in Research Chemicals:
2'-Trifluoromethylphenyl acetylene is used as a research chemical, playing a crucial role in the development and synthesis of new compounds for various scientific investigations. Its unique structure and reactivity make it a valuable tool for exploring new chemical reactions and understanding the properties of related molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2'-Trifluoromethylphenyl acetylene is utilized as a pharmaceutical intermediate. It serves as a key building block in the synthesis of various pharmaceutical compounds, contributing to the development of new drugs with potential therapeutic applications. Its presence in the molecular structure can influence the pharmacokinetics, pharmacodynamics, and overall efficacy of the final drug product.

InChI:InChI=1/C9H5F3/c10-9(11,12)7-6-8-4-2-1-3-5-8/h1-5H

Upstream product

• 79756-81-3 (+/-)-α-(o-(trifluoromethyl)phenyl)ethyl alcohol 
• 98-08-8 α,α,α-trifluorotoluene 
• 3796-19-8 2-trifluoromethylphenylmagnesium chloride 
• 395-45-9 o-(trifluoromethyl)styrene 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 444-29-1 2-iodo(trifluoromethyl)benzene 
• 219999-02-7 1-(2-Trifluormethyl-phenyl)-2-brom-aethylen 
• 79756-82-4 1-(1,2-Dibromo-ethyl)-2-trifluoromethyl-benzene 
• 40230-94-2 trimethyl((2-(trifluoromethyl)phenyl)ethynyl)silane 
• 88444-77-3 1-(2,2-dichloro-1-fluoroethenyl)-2-(trifluoromethyl)benzene 

Downstream Products

• 147344-86-3 1-(phenylethynyl)-2-(trifluoromethyl)benzene 
• 851279-10-2 1-((4-methoxyphenyl)ethynyl)-2-(trifluoromethyl)benzene 
• 917246-62-9 1-(1-bromonaphth-2-yloxy)-4-(2-trifluoromethylphenyl)but-3-yn-2-ol 
• 1025053-35-3 C₁₈H₁₀F₆N₂ 
• 835889-89-9 [Ir(P(C₆H₅)3)2(C(C₆H₅)CHC(CH₃)O)(CF₃C₆H₄CHCHCCHC₆H₄CF₃)]⁽¹⁺⁾*SbF₆^(1-)=[Ir(P(C₆H₅)3)2(C(C₆H₅)CHC(CH₃)O)(C₁₈H₁₁F₆)]SbF₆ 
• 1063716-44-8 1-(4-aminosulfonylbenzene)-4-(2-trifluoromethylbenzene)-1H-1,2,3-triazole 
• 1147014-41-2 4-((2-(trifluoromethyl)phenyl)ethynyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1118638-80-4 C₁₇H₂₀F₃N 
• 733751-58-1 1-[5-nitro-6-(2-trifluoromethyl-phenylethynyl)-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester 
• 1233042-97-1 C₂₂H₂₄F₃N₃O₈ 
• 1233043-62-3 C₂₃H₂₄F₃N₃O₉ 

Relevant academic research and scientific papers

Copper-Catalyzed Ring Opening of [1.1.1]Propellane with Alkynes: Synthesis of Exocyclic Allenic Cyclobutanes

Despite the long history and interesting properties of propellanes, these compounds still have tremendous potential to be exploited in synthetic organic chemistry. Herein we disclose an experimentally simple procedure to achieve cyclobutane-containing allenes and alkynes through a copper-catalyzed ring opening of [1.1.1]propellane and subsequent reaction with ethynes.

ALKYNE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS

Provided are compounds of formula (Ia) and pharmaceutically acceptable salts thereof, wherein A, B, R 1, R 2, m and n are as defined herein, which are active as inhibitors of S-Nitrosoglutathione reductase (GSNOR). These compounds prevent, inhibit, or suppress the action of GSNOR and are therefore useful in the treatment of GSNOR mediated diseases, disorders, syndromes or conditions such as, e.g., pulmonary hypertension, acute respiratory distress syndrome (ARDS), asthma, bronchospasm, cough, pneumonia, pulmonary fibrosis, interstitial lung diseases, cystic fibrosis and chronic obstructive pulmonary disease (COPD).

Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists

Selective thyroid hormone modulators that function as isoform-selective agonists or antagonists of the thyroid hormone receptors (TRs) might be therapeutically useful in diseases associated with aberrant hormone signaling. The most potent thyroid hormone

ANTIBACTERIAL BENZOIC ACID DERIVATIVES

The invention provides antimicrobial agents and methods of using the agents for sterilization, sanitation, antisepsis, disinfection, and treatment of infections in mammals.

Preparation of Fluorine-Containing Phenylacetylenes by the Method of Introduction of the Ethynyl Group Using 1,1-Dichloro-2,2-difluroethene

Phenylacetylenes (ArCCH) having fluoro- or trifluoromethyl substituents (o-, m-, p-F; o-, m-, p-CF3; 2,4-, 2,5-, 2,6-, 3,5-(CF3)2) have been prepared from bromobenzenes (ArBr) and benzenes (ArH) using 1,1,-dichloro-2,2-difluoroethene (1) by a two-step route: ArLi or ArMgBr->ArCF=CCl2->ArCCLi.Upon careful treatment at -70 deg C with 1, o-fluorophenyllithium gave o-FC6H4CF=CCl2 in good yield, together with benzyne-derived products, such as o-(o-FC6H4)C6H4CF=CCl2.Lithiation of m-bis(trifluoromethyl)benzene at 0 deg C for 9 h (24 h) followed by treatment with bromine gave 1-bromo-2,4-, 2,6-, and 3,5-bis(trifluoromethyl)benzene in 35 (38), 31 (36), and 8percent (6percent) yield, respectively.

Choix des methodes pour la synthese univoque de carbures acetyleniques. Troisieme partie : Arylacetylenes et aryl-1 alcynes-1

The range of applicability of six syntheses of pure alkynes with one aryl group has been defined; a short review of other possible procedures is included.We have specified the best method to obtain selectively the alkynes Ar-CCH and Ar-CC-R, according to the nature of the substituents of the aryl group and according to the developed structure of the R group.It is thus possible to recommend with the largest probability of success the method to obtain, in homogenous series, alkynes corresponding to still more complicated structures.