26228-68-2

Basic information

• Product Name: 4-(Aminomethyl)-1-methyl-piperidin-4-ol
• Synonyms: 4-(aminomethyl)-1-methylpiperidin-4-ol dihydrochloride;4-piperidinol, 4-(aminomethyl)-1-methyl-;4-Aminomethyl-1-methylpiperidin-4-ol;4-(aminomethyl)-1-methylpiperidin-4-ol(SALTDATA: 2HCl);4-aMinoMethyl-4-hydroxy-1-Methylpiperidine(HCl)
• CAS NO: 26228-68-2
• Molecular Formula: C₇H₁₆N₂O
• Molecular Weight: 144.21
• Mol File: 26228-68-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 255.691 °C at 760 mmHg
• Flash Point: 108.439 °C
• Appearance: /
• Density: 1.048 g/cm³
• Vapor Pressure: 0.00243mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: 4-(Aminomethyl)-1-methyl-piperidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Aminomethyl)-1-methyl-piperidin-4-ol(26228-68-2)
• EPA Substance Registry System: 4-(Aminomethyl)-1-methyl-piperidin-4-ol(26228-68-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 26228-68-2(Hazardous Substances Data)

Usage

General Description

"4-(Aminomethyl)-1-methyl-piperidin-4-ol" is a chemical compound with a molecular weight of 144.21 g/mol and it exists as a white to off-white solid. Due to its structure which features both amine and alcohol functional groups along with a piperidinyl ring, it finds usage in various chemical synthesis and pharmaceutical applications. It's a part of the derivatives of piperidine, a class of organic compounds with a five-membered ring with one nitrogen atom. However, it is recommended to handle this compound with care as it may cause skin and eye irritation and its safety in human health and the environment is not fully evaluated.

InChI:InChI=1/C7H16N2O/c1-9-4-2-7(10,6-8)3-5-9/h10H,2-6,8H2,1H3

Upstream product

• 116250-49-8 1-methyl-4-(nitromethyl)piperidin-4-ol 
• 392331-66-7 4-aminomethyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester 
• 150358-78-4 4-Cyano-4-trimethylsilyloxy-1-methyl-piperidine 
• 1445-73-4 1-Methyl-4-piperidone 

Downstream Products

• 5053-07-6 8-methyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one 
• 1361951-07-6 1-methyl-4-(((3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)methyl)piperidin-4-ol 
• 1225379-48-5 1-methyl-4-[({5-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridin-2-yl}amino)methyl]piperidin-4-ol 
• 138300-83-1 4-acetamidomethyl-4-hydroxy-1-methylpiperidine 

Relevant articles and documents

Histone Deacetylase Inhibitors and Methods of Use Thereof

The present invention relates to methods of modulating activity of histone deacetylases (HDACs). The present invention also relates to methods of treating HDAC-associated diseases including, but not limited to, cancers, inflammatory disorders, and neurodegenerative disorders. The present invention also provides novel compounds and compositions thereof and methods of preparation of the same. The present invention also includes methods of inhibiting HDACs, and methods of treating HDAC-associated diseases using the compounds of the invention.

QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR INHIBITORS

Compounds of formula (Ι') that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Pyrrolo [3,2-C] Pyridine-4-One 2-Indolinone Protein Kinase Inhibitors

The present invention relates to pyrrolo[3,2-c]pyridine-4-one 2-indolinone compounds of Formula (I) and their pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8X, Y and have the meaning cited in the specification.