262295-75-0Relevant academic research and scientific papers
N-arylpiperazine-1-carboxamide derivatives: A novel series of orally active nonsteroidal androgen receptor antagonists
Kinoyama, Isao,Taniguchi, Nobuaki,Kawaminami, Eiji,Nozawa, Eisuke,Koutoku, Hiroshi,Furutani, Takashi,Kudoh, Masafumi,Okada, Minoru
, p. 402 - 409 (2007/10/03)
A novel series of N-arylpiperazine-1-carboxamide derivatives was synthesized and their androgen receptor (AR) antagonist activities and in vivo antiandrogenic properties were evaluated. Reporter assays indicated that trans-2,5-dimethylpiperazine derivativ
Cyanophenyl derivative
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Page column 12; 13, (2010/11/30)
This application relates to a piperazino-substituted novel cyanophenyl derivative in which a substituted carbamoyl or substituted sulfamoyl group having an aryl, heterocyclic or the like group that may have a substituent group is bonded to one nitrogen atom on the piperazine ring. The compound of this application has an anti-androgen action and is useful in preventing or treating prostatic cancer, benign prostatic hyperplasia and the like diseases.
CYANOPHENYL DERIVATIVES
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, (2008/06/13)
This application relates to a piperazino-substituted novel cyanophenyl derivative in which a substituted carbamoyl or substituted sulfamoyl group having an aryl, heterocyclic or the like group that may have a substituent group is bonded to one nitrogen atom on the piperazine ring. The compound of this application has an anti-androgen action and is useful in preventing or treating prostatic cancer, benign prostatic hyperplasia and the like diseases.
