2624-48-8 Usage
Uses
Used in Pharmaceutical Industry:
Nicotine bi-L-(+)-tartrate is used as an active ingredient in smoking cessation products for its ability to reduce cravings and withdrawal symptoms associated with quitting smoking. It is particularly effective in nicotine replacement therapy (NRT), where it helps individuals gradually reduce their dependence on nicotine by providing a controlled dose of the substance.
Used in Medical Applications:
In the medical field, the bi-L-(+)-tartrate form of nicotine is utilized for its water-soluble properties, making it suitable for various pharmaceutical formulations and treatments. Its ability to bind to nicotine receptors in the brain allows for potential therapeutic applications in managing nicotine addiction and related health issues.
Check Digit Verification of cas no
The CAS Registry Mumber 2624-48-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,2 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2624-48:
(6*2)+(5*6)+(4*2)+(3*4)+(2*4)+(1*8)=78
78 % 10 = 8
So 2624-48-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2.2C4H6O6/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;2*5-1(3(7)8)2(6)4(9)10/h2,4,6,8,10H,3,5,7H2,1H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t;2*1-,2-/m.11/s1
2624-48-8Relevant academic research and scientific papers
Disposition kinetics of nicotine and cotinine enantiomers in rabbits and beagle dogs
Jacob III,Benowitz,Copeland,Risner,Cone
, p. 396 - 400 (2007/10/02)
The disposition kinetics of nicotine and cotinine enantiomers was determined in rabbits. The clearance of (R)-nicotine was similar to that of (S)-nicotine, but clearance of (R)-cotinine was twice that of (S)-cotinine. Fractional conversions of both enantiomers of nicotine to cotinine were ~50%. These results suggest that in rabbits the biotransformation pathways of cotinine, but not nicotine, are influenced by stereochemistry. The disposition kinetics of nicotine enantiomers in beagle dogs was also studied. In dogs, the clearance of (R)-nicotine was slightly greater than the clearance of (S)-nicotine. Methods for the synthesis of (R)-nicotine and (R)-cotinine of high enantiomeric purity and a gas chromatographic method for determination of nicotine enantiomeric purity are described.
