262419-95-4

Basic information

• Product Name: 2'-(2-t-butyldiphenylsilyloxyphenyl)-2'-thiazoline-4'-carboxaldehyde
• Synonyms: 2'-(2-t-butyldiphenylsilyloxyphenyl)-2'-thiazoline-4'-carboxaldehyde
• CAS NO: 262419-95-4
• Molecular Weight: 445.657
• Mol File: 262419-95-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-(2-t-butyldiphenylsilyloxyphenyl)-2'-thiazoline-4'-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-(2-t-butyldiphenylsilyloxyphenyl)-2'-thiazoline-4'-carboxaldehyde(262419-95-4)
• EPA Substance Registry System: 2'-(2-t-butyldiphenylsilyloxyphenyl)-2'-thiazoline-4'-carboxaldehyde(262419-95-4)

Safety Data

• Hazardous Substances Data: 262419-95-4(Hazardous Substances Data)

Upstream product

• 262419-94-3 methyl-2'-(2-t-butyldiphenylsilyloxyphenyl)-2'-thiazoline-4'-carboxylate 
• 611-20-1 salicylonitrile 
• 115921-07-8 (R)-2-(2'-hydroxyphenyl)-4-methoxycarbonyl-4,5-dihydrothiazole 

Downstream Products

• 69772-54-9 (4'S,4''R)-2'-(2-hydroxyphenyl)-3''-methyl-2'',3'',4'',4',5'-hexahydro-[2,4']-bisthiazolyl-4''-carboxylic acid 
• 69772-54-9 (4'R,2''R,4''R)-2'-(2-hydroxyphenyl)-3''-methyl-2'',3'',4'',4',5'-hexahydro-[2,4']-bisthiazolyl-4''-carboxylic acid 
• 69772-54-9 (4'S,2''R,4''R)-2'-(2-hydroxyphenyl)-3''-methyl-2'',3'',4'',4',5'-hexahydro-[2,4']-bisthiazolyl-4''-carboxylic acid 
• 83053-39-8 2'-(2-hydroxyphenyl)-2'-thiazole-4'-carboxaldehyde 

Relevant articles and documents

An improved stereocontrolled synthesis of pyochelin, siderophore of Pseudomonas aeruginosa and Burkholderia cepacia

A considerably improved stereocontrolled synthesis of pyochelin, a hydroxyphenylthiazolinylthiazolidine type of siderophore common to most strains of Pseudomonas aeruginosa and Burkholderia cepacia is described. 2'- (2-Hydroxyphenyl)-2'-thiazoline-4'-carboxaldehyde, a key molecule involved in this synthesis has been prepared by reduction of 2'-(2-hydroxyphenyl)-2'- thiazoline-4'-(N-methoxy,N-methyl) carboxamide with lithium aluminium hydride. The aldehyde was further coupled with (R)-N-methylcysteine to yield pyochelin. Under the conditions reported, epimerization at the C-4' center was considerably diminished.