2626-64-4Relevant academic research and scientific papers
Palladium-Catalyzed Arylation of Unactivated γ-Methylene C(sp3)-H and δ-C-H Bonds with an Oxazoline-Carboxylate Auxiliary
Ling, Peng-Xiang,Fang, Sheng-Long,Yin, Xue-Song,Chen, Kai,Sun, Bo-Zheng,Shi, Bing-Feng
supporting information, p. 17503 - 17507 (2016/01/25)
A palladium-catalyzed arylation of unactivated γ-methylene C(sp3)-H and remote δ-C-H bonds by using an oxazoline-carboxylate directing group has been developed. Arylation occurs with a broad substrate scope and high tolerance of functional groups (i.e., halogen, nitro, cyano, ether, trifluoromethyl, amine, and ester). The oxazoline-type auxiliary can be removed under acidic conditions.
Thiadiaziridine 1,1-Dioxides: Synthesis and Chemistry
Timberlake, Jack W.,Alender, Jeff,Garner, Archie W.,Hodges, Melvin L.,Oezmeral, Cenan,et al.
, p. 2082 - 2089 (2007/10/02)
The synthesis and chemical reactions of a series of thiadiaziridine 1,1-dioxides (2) are described.The thermal stability is highly dependent on the R group and in one case (R = tert-octyl) is postulated that the thermolysis initially produces a diradical intermediate which can be trapped or further fragments to give a nitrene.A temperature-dependent NMR study on the coalescence of the diastereotopic α-methyl protons of 2b gives a ΔG = 20 kcal*mol-1.
