2627-62-5

Upstream product

• 88121-20-4 3′,5′-O-(1,1,3,3-tetraisopropyldisiloxyl)-2′-O-(trifluormethylsulfonyl)adenosine 
• 69304-45-6 3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine 
• 85335-82-6 3',5'-O-(1,1,3,3-tetraisopropyldisilox-1,3-diyl)-9-(2-chloro-2-deoxy-β-D-arabinofuranosyl)adenine 

Downstream Products

• 13276-53-4 9-(2'-deoxy-β-D-threo-ribofuranosyl)-adenine 
• 184297-04-9 Thiocarbonic acid O-[(2R,3R,4R,5R)-5-(6-amino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-tetrahydro-furan-3-yl] ester O-phenyl ester 
• 184297-08-3 Thiocarbonic acid O-[(2R,3R,4S,5R)-5-(6-amino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-tetrahydro-furan-3-yl] ester O-phenyl ester 

Relevant academic research and scientific papers

Deoxygenative [1,2]-hydride shift rearrangements in nucleoside and sugar chemistry: Analogy with the [1,2]-electron shift in the deoxygenation of ribonucleotides by ribonucleotide reductases

(Chemical Equation Presented) A variant of the semipinacol rearrangement that was observed in our laboratory has been applied to the synthesis of several furanose and pyranose derivatives. The process consists of an "orchestrated" [1,2]-hydride shift with

A packing-density metric for exploring the interior of folded RNA molecules

The intricate architectures of RNA molecules often contain expansive close-packed interfaces. The folding of the well-defined P4-P6 RNA domain was challenged by using a series of 2′-modified nucleotides with a narrow range of molecular volumes. The resulting folding interferences (see picture) reflect the spatial environment of the 2′-hydroxy groups and thereby define a packing-density metric.