26278-65-9

Basic information

• Product Name: 3,3-DiMethyl-3,4-dihydroisoquinolin-1(2H)-one
• Synonyms: 3,3-DiMethyl-3,4-dihydroisoquinolin-1(2H)-one;3,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-1-one;3,3-Dimethyl-3,4-dihydro-isoquinolin-1-ol
• CAS NO: 26278-65-9
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.22702
• Mol File: 26278-65-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,3-DiMethyl-3,4-dihydroisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-DiMethyl-3,4-dihydroisoquinolin-1(2H)-one(26278-65-9)
• EPA Substance Registry System: 3,3-DiMethyl-3,4-dihydroisoquinolin-1(2H)-one(26278-65-9)

Safety Data

• Hazardous Substances Data: 26278-65-9(Hazardous Substances Data)

Usage

General Description

3,3-DiMethyl-3,4-dihydroisoquinolin-1(2H)-one is a chemical compound with the molecular formula C12H15NO. It is a derivative of isoquinoline and contains a dihydroisoquinolinone core structure. 3,3-DiMethyl-3,4-dihydroisoquinolin-1(2H)-one has potential applications in medicinal chemistry and pharmaceutical research due to its unique structure and potential biological activity. It may be used as a building block for the synthesis of new drug candidates or as a starting material for the development of novel pharmaceuticals. Additionally, 3,3-DiMethyl-3,4-dihydroisoquinolin-1(2H)-one may also be of interest to researchers studying the structure-activity relationships of isoquinoline derivatives and their potential therapeutic applications.

Upstream product

• 201230-82-2 carbon monoxide 
• 122-09-8 Phentermin 
• 64-19-7 acetic acid 

Relevant articles and documents

NH2 as a directing group: From the cyclopalladation of amino esters to the preparation of benzolactams by palladium(II)-catalyzed carbonylation of N-unprotected arylethylamines

An unusual NH2-directed Pd(II)-catalyzed carbonylation of quaternary aromatic α-amino esters to yield benzolactams has been developed. The steric hindrance around the amino group is pivotal for the success of the process. The stoichiometric cyclometalation of a variety amino esters has been studied in order to evaluate the influence of the different variables (size of the metallacycle, aromatic ring substituents, and steric bulk) in the process, and a complete kinetico-mechanistic study of the cyclopalladation process has been carried out. The experimental results indicate that the full substitution of the carbon in the α position of the amino esters plays an important role in their cyclopalladation reaction. The reaction shows a strong bias toward six-membered lactams over the five-membered analogues, which can be explained by a greater reactivity of the six-membered palladacycles.