262853-72-5

Upstream product

• 2524-64-3 chlorophosphoric acid diphenyl ester 
• 25605-70-3 benzyl 2-acetamido-6-O-acetyl-3-O-<(R)-1-carboxyethyl>-2-deoxy-α-D-glucopyranoside 1',4-lactone 

Relevant academic research and scientific papers

Optimization of UDP-N-acetylmuramic acid synthesis

UDP-N-acetylmuramic acid (UDP-MurNAc) is a substrate of MurC, an important enzyme in the intracellular pathway of bacterial peptidoglycan biosynthesis. Various approaches towards preparation of UDP-Mur/VAc have been published but these synthetic preparations were shown to include many problematic steps. An optimization study with the focus on muramyl phosphate and UMP-morpholidate coupling was performed, resulting in a synthetic procedure enabling robust and easily reproducible production on a multi-gram scale.

Multi gram synthesis of UDP-N-acetylmuramic acid

As part of an effort to discover novel antibacterial agents, a new and efficient synthesis was established in order to provide a large amount of UDP-N-acetylmuramic acid (UDP-MurNAc).