262856-93-9Relevant academic research and scientific papers
Derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing Salmeterol
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Page column 9, (2010/02/05)
The present invention refers to new derivatives of the 6-(4-phenylbutoxy)hexylamine of the general formula (I): wherein: R1is CHO or CHOR3OR4, where R3and R4independently are C1-C6alkyl, aralkyl, or they form 5 or 6 membered cyclic acetals; and R2is H, benzyl or an alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl or acyl group; and to a process for its obtention. The invention also refers to a new process for obtaining Salmeterol or its pharmaceutically acceptable salts, characterized in that reaction of an organometallic compound of the general formula (13) is carried out in an inert solvent at low temperature with a synthetic intermediate of the general formula (I), wherein R1is CHO, and R2is an alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl or acyl group.
