26288-57-3

Upstream product

• 138900-61-5 1-(triisopropylsilyl)-3-(4-chlorophenyl)pyrrole 
• 122453-98-9 4-(4-Chloro-phenyl)-1H-pyrrole-3-carboxylic acid 
• 1073-67-2 4-vinylbenzyl chloride 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 7560-44-3 methyl 4-chlorocinnamate 
• 106-39-8 bromochlorobenzene 
• 76304-28-4 dimethyl 3-(4-chlorophenyl)-1H-pyrrole-2,4-dicarboxylate 
• 68001-86-5 methyl (Z)-3-(4-chlorophenyl)-2-isocyanoacrylate 
• 68185-82-0 (E)-3-(4-Chloro-phenyl)-2-isocyano-acrylic acid methyl ester 
• 20754-21-6 methyl 3-(4-chlorophenyl)propenoate 

Downstream Products

• 1345502-19-3 C₁₅H₁₇ClN₂O₂ 

Relevant academic research and scientific papers

One-step synthesis of 3-aryl- and 3,4-diaryl-(1H)-pyrroles using tosylmethyl isocyanide (TOSMIC)

(matrix presented) A one-step synthesis of 3-aryl and 3,4-diaryl-(1H)-pyrroles from TOSMIC and commercially available or readily synthesized arylalkenes is reported. Optimal conditions were found to be NaOtBu in DMSO. The methodology was particularly efficient (yields > 65%) when electron poor aryl groups were attached to the alkene.

Metal-Free Directed C?H Borylation of Pyrroles

Robust strategies to enable the rapid construction of complex organoboronates in selective, practical, low-cost, and environmentally friendly modes remain conspicuously underdeveloped. Here, we develop a general strategy for the site-selective C?H borylation of pyrroles by using only BBr3 directed by pivaloyl groups, avoiding the use of any metal. The site-selectivity is generally dominated by chelation and electronic effects, thus forming diverse C2-borylated pyrroles against the steric effect. The formed products can readily engage in downstream transformations, enabling a step-economic process to access drugs such as Lipitor. DFT calculations (wB97X-D) demonstrate the preferred positional selectivity of this reaction.

Synthesis of 3-Arylpyrroles and 3-Pyrrolylacetylenes by Palladium-Catalyzed Coupling Reactions

Efficacious methods for the synthesis of 3-arylpyrroles or 3-pyrrolylacetylenes are described based on the palladium-catalyzed coupling of appropriate 1-(triisopropylsilyl)-3-substituted pyrroles with aryl halides or monosubstituted acetylenes and subsequ

Arylpyrrole insecticidal acaricidal and nematicidal agents and methods for the preparation thereof

This invention is directed to certain novel insecticidal, acaricidal and nematicidal arylpyrrole agents and a method for controlling insects, acarids and nematodes therewith. The invention also is directed to a method for protecting growing plants from insect, acarid and nematode attack by applying to said plants or the soil in which they are growing, an insecticidally, acaricidally or nematicidally effective amount of a novel arylpyrrole compound. The present invention further is directed to a method for the preparation of the arylpyrrole compounds.

Method of controlling phytopathogenic fungi

This invention is directed to a method for the control of phytopathogenic fungi by contacting the same with a cyano- or nitroarylpyrrole compound, or by applying said pyrrole compound to the foliage of a plant susceptible to disease caused by said pathogens.

Method of and bait compositions for controlling mollusks

This invention relates to methods of controlling mollusks with arylpyrrole compounds and to bait compositions containing a molluscicidally effective amount of an arylpyrrole compound.