2629-75-6Relevant academic research and scientific papers
Surface-active ionic liquids for micellar extraction of piperine from black pepper
Ressmann, Anna K.,Zirbs, Ronald,Pressler, Martin,Gaertner, Peter,Bica, Katharina
, p. 1129 - 1137 (2013)
We present the application of ionic liquid-aqueous micellar solutions as isolation media for the pharmaceutically active ingredient piperine from black pepper. Several surface-active ionic liquids including a biodegradable betaine derivative were used for the extraction of piperine, and a strong correlation between extraction yield and the critical micelle concentration of the respective ionic liquid was found. A scaled strategy for the isolation of piperine was developed that allowed recovery and recycling of the aqueous ionic liquid micellar solution for five runs without any loss in extraction efficiency.
PHARMACEUTICAL COMPOSITION HAVING A CATIONIC EXCIPIENT
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Page/Page column 19; 20, (2008/06/13)
The invention relates to a pharmaceutical composition comprising a pharmaceutically effective amount of a pharmaceutically active substance and a pharmaceutically acceptable carrier comprising a cationic excipient, wherein said cationic excipient is a labile ester of betaine and a lipophilic alcohol having at least one primary hydroxyl group. The invention also relates to the use of a labile ester of betaine and a lipophilic alcohol having at least a primary hydroxyl group as a cationic excipient in a carrier for a pharmaceutical composition comprising a pharmaceutically active substance.
