26292-51-3

Upstream product

• 114840-55-0 2,2-bis-methanesulfonyl-N-methyl-acetimidic acid methyl ester 
• 1623-08-1 phosphoric acid dibenzyl ester 
• 67746-43-4 dibenzyl N,N-diethylphosphoramidite 
• 100-51-6 benzyl alcohol 
• 67-56-1 methanol 
• 1355235-82-3 dibenzyl 2-(3-([bis-[(benzyl)oxy]]phosphoryl)oxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-ylphosphate 
• 173170-93-9 benzyl methyl N,N-diisopropylphosphoramidite 
• 176506-97-1 dibenzyl phosphoroiodidate 
• 74-88-4 methyl iodide 
• 100-44-7 benzyl chloride 
• 216018-15-4 Phosphorous acid benzyl ester methyl ester 4-methyl-benzyl ester 
• 53148-15-5 tetramethylammonium dibenzyl phosphate 
• 13471-32-4 N,N’-di-p-tolyl-O-methylisourea 

Downstream Products

• 133660-55-6 Benzyl methyl chlorophosphate 
• 1623-08-1 phosphoric acid dibenzyl ester 

Relevant academic research and scientific papers

Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster

Natural product discovery has been boosted by genome mining approaches, but compound purification is often still challenging. We report an enzymatic strategy for stable isotope labeling of phosphonates in extract (SILPE) that facilitates their purificatio

Mechanistic studies on regioselective dephosphorylation of phosphate prodrugs during a facile synthesis of antitumor phosphorylated 2-phenyl-6,7-methylenedioxy-1H-quinolin-4-one

Phosphorylation of 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxy- 1Hquinolin- 4-one (1) afforded diphosphate 2. We found that, upon treatment with methanol under mild conditions, 2 can undergo facile and highly regioselective dephosphorylation to give

Selective phosphorylation on primary alcohols of unprotected polyols

The triad tribenzylphosphite-iodine-pyridine offers a general selective method for phosphorylation reactions of primary alcohols of unprotected α-diols and polyols. A mechanistic study by 31P NMR allowed to evidence the formation, from iododibenzyl phosphate and pyridine, of a very reactive pyridinium salt intermediate. This analysis shows that pyridine behaves as a covalent catalyst like DMAP in acylation reactions from acylchloride. Due to its steric hindrance and high reactivity, this species appears to be the efficient selective phosphorylation reagent but leads to dibenzylphosphoric esters. Under mild conditions, the cleavage of benzyl groups gives monoester phosphoric acid.

Reactions of benzyl methyl substituted-benzyl phosphites with tert- butyl hypochlorite: 'Balanced TS' validating reactivity/selectivity principle

Reactions of a series of several benzyl methyl substituted-benzyl phosphites with tert-butyl hypochlorite were investigated. The reactions produced phosphates, isobutene, alkyl chlorides, and benzyl chlorides via phosphonium chlorides as intermediates. Fu

A NEW, CONVENIENT AND EFFICIENT GENERAL PROCEDURE FOR THE CONVERSION OF ALCOHOLS INTO THEIR DIBENZYL PHOSPHOROTRIESTERS USING N,N-DIETHYL DIBENZYL PHOSPHORAMIDITE

A general procedure is described for the near-quantitative preparation of alkyl dibenzyl phosphates by treating primary, secondary or tertiary alcohols with N,N-diethyl dibenzyl phosphoramidite/1H,5-methyltetrazole followed by mild oxidation of the resultant alkyl dibenzyl phosphites with 3-chloroperoxybenzoic acid.