2630-37-7

Usage

Uses

Used in Pharmaceutical Industry:
[S,(-)]-3-Oxocyclopentaneacetic acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique α-keto acid functionality allows for versatile chemical reactions, facilitating the creation of new drug candidates with potential therapeutic benefits.
Used in Organic Synthesis:
In the field of organic synthesis, [S,(-)]-3-Oxocyclopentaneacetic acid is utilized as a building block for the construction of complex organic molecules. Its reactivity and structural features make it a valuable component in the synthesis of a wide range of organic compounds, contributing to the development of new materials and chemical entities with diverse applications.

Upstream product

• 68366-28-9 (-)-Methyl-2-(methoxycarbonyl)-3-oxocyclopentanacetat 
• 57020-97-0 ethyl 5-oxocyclopent-1-en-1-carboxylate 
• 74786-02-0 1-(tert-butyldimethylsilyloxy)-1-tert-butoxyethylene 
• 68366-27-8 (1R,2S,3R)-3-Hydroxy-2-(methoxycarbonyl)cyclopentanessigsaeure-methylester 
• 6228-98-4 phenylthioacetylene 
• 36601-73-7 2-carbomethoxycyclopent-2-enone 

Downstream Products

• 2630-38-8 (S)-(-)-methyl 3-oxocyclopentylacetate 

Relevant academic research and scientific papers

Enantioselective conjugate additions of silylketene acetals to 2-carboxycyclopentenones promoted by chiral Ti complexes

The conjugate addition of silylketeneacetals to 2-carbalkoxycyclopentenones 1 promoted by TADDOL · TiCl2 complexes was studied. The reactions are highly syn selective. The enantioselectivity depends on the size of the substrate ester group, wit

Catalytic enantioselective [2+2]-cycloaddition reaction of 2-methoxycarbonyl-2-cyclopenten-1-one by chiral copper catalyst

A new catalytic system for enantioselective [2+2]-cycloaddition reaction of 2-methoxycarbonyl-2-cyclopenten-1-one with thioacetylene derivatives is described. The use of a catalytic amount (20-30 mol%) of copper(II) salt with chiral bis-pyridine ligand wa

An asymmetric enzyme-catalyzed retro-claisen reaction for the desymmetrization of cyclic β-diketones

Unsymmetrical is beautiful: Enzymatic desymmetrization offers a mild route to chiral synthons with, in principles, 100% yield and absolute optical purity. The technique has been applied to bicyclic β-diketones for the first time, through a novel enzymatic retro-Claisen reaction, to yield chiral cyclic keto acids in up to 91% yield and 94% ee (see scheme, step a).