2630-44-6Relevant academic research and scientific papers
Catalytic enantioselective [2+2]-cycloaddition reaction of 2-methoxycarbonyl-2-cyclopenten-1-one by chiral copper catalyst
Takenaka, Yosuke,Ito, Hisanaka,Hasegawa, Mineki,Iguchi, Kazuo
, p. 3380 - 3388 (2007/10/03)
A new catalytic system for enantioselective [2+2]-cycloaddition reaction of 2-methoxycarbonyl-2-cyclopenten-1-one with thioacetylene derivatives is described. The use of a catalytic amount (20-30 mol%) of copper(II) salt with chiral bis-pyridine ligand wa
An asymmetric enzyme-catalyzed retro-claisen reaction for the desymmetrization of cyclic β-diketones
Grogan, Gideon,Graf, Juergen,Jones, Aileen,Parsons, Simon,Turner, Nicholas J.,Flitsch, Sabine L.
, p. 1111 - 1114 (2007/10/03)
Unsymmetrical is beautiful: Enzymatic desymmetrization offers a mild route to chiral synthons with, in principles, 100% yield and absolute optical purity. The technique has been applied to bicyclic β-diketones for the first time, through a novel enzymatic retro-Claisen reaction, to yield chiral cyclic keto acids in up to 91% yield and 94% ee (see scheme, step a).
Enantioselective conjugate additions of silylketene acetals to 2-carboxycyclopentenones promoted by chiral Ti complexes
Bernardi, Anna,Karamfilova, Katia,Sanguinetti, Silvia,Scolastico, Carlo
, p. 13009 - 13026 (2007/10/03)
The conjugate addition of silylketeneacetals to 2-carbalkoxycyclopentenones 1 promoted by TADDOL · TiCl2 complexes was studied. The reactions are highly syn selective. The enantioselectivity depends on the size of the substrate ester group, wit
