263017-10-3

Upstream product

• 391678-32-3 (2R)-t-Butoxycarbonylamino-2-methyl-3-butenal 
• 513-35-9 2-methyl-but-2-ene 
• 7758-19-2 sodium chlorite 
• 252953-41-6 (R)-N-(tert-butoxycarbonyl)-4-vinyl-2,2,4-trimethyl-3-oxazolidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 263016-97-3 (R)-2-((tert-butoxycarbonyl)amino)-2-methyl-3-buten-1-ol 

Relevant academic research and scientific papers

AMINO ALCOHOL DERIVATIVES

The present invention relates to compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof, esters thereof or other derivatives: wherein R1 and R2 are a hydrogen atom, an amino protecting group; R3 is a hydrogen atom, a hydroxy protecting group; R4 is a lower alkyl group; n is an integer from 1 to 6; X is an ethylene group; Y is a C1-C10 alkylene group, a C1-C10 alkylene group substituted with 1 to 3 substituents selected from substituent group a and b; R5 is an aryl group; R6 and R7 are a hydrogen atom, a group selected from substituent group a; with the proviso when R5 is a hydrogen atom, Y is not a single bond or a straight chain C1-C10 alkylene group.

Amino alcohol derivatives

Compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof, esters thereof or other derivatives: wherein R1 and R2 are a hydrogen atom, an amino protecting group; R3 is a hydrogen atom, a hydroxy protecting group; R4 is a lower alkyl group; n is an integer from 1 to 6; X is an ethylene group; Y is a C1-C10 alkylene group, a C1-C10 alkylene group substituted with 1 to 3 substituents selected from substituent group a and b; R5 is an aryl group; R6 and R7 are a hydrogen atom, a group selected from substituent group a; with the proviso when R5 is a hydrogen atom, Y is not a single bond or a straight chain C1-C10 alkylene group.

A straightforward synthesis of both enantiomers of α-vinylalanine and α-ethynylalanine

This report describes the synthesis of enantiomerically pure (S)- and (R)-α-vinylalanines and (S)- and (R)-α-ethynylalanines, four quaternary α- amino acids, using a straightforward synthetic route and starting from (S)- and (R)-N-Boc-N,O-isopropylidene-α-methylserinals. (C) 1999 Elsevier Science Ltd.