26306-64-9Relevant articles and documents
Design, synthesis and nematicidal activitives of trifluorobutene amide derivatives against Meloidogyne incognita
Yang, Haiping,Zhang, Ruifeng,Li, Zhong,Maienfisch, Peter,Xu, Xiaoyong
, (2021)
Plant parasitic nematodes have always been a pressing problem in the field of plant protection. Well-established chemical nematicides, especially organophosphorus and carbamates are the most used products for nematode control worldwide. Due to long-term overuse, they have developed serious resistance and new innovative solutions are urgently required. In this study, thirty-one novel trifluorobutene amide derivatives were designed and synthesized, and their nematicidal activities were determined. Three different synthetic methods have been developed for the final amidation reaction enabling the successfully syntheses of the target compounds independently from the nucleophilicities of the substrate amino group. Most target compounds showed good nematicidal activity in our in vitro test. Among all the compounds, compounds A8 and A23 exhibited excellent nematicidal activity against Meloidogyne incognita, their LC50 values are 2.02 mg L?1 and 0.76 mg L?1, respectively. In particular, compound A23 has found to be almost as active as the commercial nematicide fluensulfone. Furthermore, most compounds gave full control (100% inhibition) of M. incognita at 40 mg L?1 in the in vivo tests in sandy soil, the best compounds were further investigated for in vivo activity in matrix soil. Among the compound tested, compound A8 showed excellent in vivo nematicidal activity. At a concentration of 5 mg L?1 still 56% inhibition was observed. The results of our study indicate that compound A8 possesses excellent in vitro and in vivo nematicidal activity, and can be considered as promising lead molecule for further modification.
A bactericide composition and the preparation and use thereof (by machine translation)
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Paragraph 0072; 0073, (2017/08/26)
The invention relates to the field of agricultural fungicide, discloses a fungicide composition, a preparation of the fungicide composition and application of the preparation, and in particular relates to a fungicide composition for preventing gray mold, a preparation of the fungicide composition and application of the preparation. The fungicide composition contains fludioxonil and pyrazolecarboxamide compounds, which have the weight ratio of 1:1000-1000:1. The pesticide preparation prepared from the fungicide composition is used for preventing gray mold, has treatment and protection functions, has good synergism, has good fungicidal effect, and is safe to crops, and the application frequency of the pesticide preparation can be reduced.
Design, synthesis and antifungal activity of novel furancarboxamide derivatives
Wen, Fang,Jin, Hong,Tao, Ke,Hou, Taiping
, p. 244 - 251 (2016/05/24)
Twenty-seven novel furancarboxamide derivatives with a diphenyl ether moiety were synthesized and evaluated for their antifungal activity against Rhizoctonia solani, Botrytis cirerea, Valsa Mali and Sphaceloma ampelimum. Antifungal bioassay results indicated that most compounds had good or excellent fungicidal activities for R. solani and S. ampelimum at 20 mg L-1. Among synthesized compounds, compound 18e showed a greater inhibitory effect against S. ampelimum, with half maximal effective concentration (EC50) values of 0.020 mg L-1. This strong activity rivals currently used commercial fungicides, such as Boscalid and Carbendazim, and has great potential as a lead compound for future development of novel fungicides.