26307-49-3

Upstream product

• 100-39-0 benzyl bromide 
• 4224-96-8 3-phenyl-1-p-tolylprop-2-en-1-one 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 
• 100-51-6 benzyl alcohol 
• 94404-56-5 ((Z)-2-Benzyl-3-imino-1-phenyl-3-p-tolyl-propenyl)-phenyl-amine 

Relevant academic research and scientific papers

Iridium-Catalyzed Alkylation of Secondary Alcohols with Primary Alcohols: A Route to Access Branched Ketones and Alcohols

Under borrowing hydrogen conditions, NHC-iridium(I) catalyzed the direct or one-pot sequential synthesis of α,α-disubstituted ketones via the alkylation of secondary alcohols with primary alcohols is reported. Notably, the present approach provides a new method for the facile synthesis of α,α-disubstituted ketones and featured with several characteristics, including a broad substrate scope, using easy-to-handle alcohols as starting materials, and performing the reactions under aerobic conditions. Moreover, the selective one-pot formation of β,β-disubstituted alcohols was achieved by the addition of an external hydrogen source to the reaction mixture.

Mild and Regiospecific Reduction of Masked 1,3-Dicarbonyl Derivatives to Monocarbonyl Compounds and Primary and Secodary Amines

The regiospecific reduction of masked 1,3-dicarbonyl compounds to the corresponding saturated monocarbonyl 3 or iminic 4 compounds via 3-amino-2-alkenimines 1 is described.The formation of 3 and 4 can be explained in terms of a double reduction process from 1.A simple method for the synthesis of primary and secondary amines 6 is also described.