263247-46-7Relevant articles and documents
Borane-Catalyzed Chemoselectivity-Controllable N-Alkylation and ortho C-Alkylation of Unprotected Arylamines Using Benzylic Alcohols
Meng, Shan-Shui,Tang, Xiaowen,Luo, Xiang,Wu, Ruibo,Zhao, Jun-Ling,Chan, Albert S. C.
, p. 8397 - 8403 (2019)
An unprecedented protocol for the efficient and highly chemoselective alkylation of unprotected arylamines using alcohols catalyzed by B(C6F5)3 has been developed. The reaction gives N-alkylated products and ortho C-alkylated products in different solvents in good chemoselectivities and yields. Control experiments and DFT calculations indicated that the borane underwent alcohol/arylamine exchange to ensure catalytic activity, and a possible mechanism involving a carbocation is proposed.
Oxidative Kinetic Resolution of Acyclic Amines Based on Equilibrium Control
Akiyama, Takahiko,Ito, Yui,Miyashita, Hiromitsu,Saito, Kodai,Yamanaka, Masahiro
, (2020/04/10)
An oxidative kinetic resolution of racemic acyclic amines was developed using an imine derivative as the resolving reagent and chiral phosphoric acid as the catalyst to give enantiomers in good yields with high to excellent enantioselectivities. The key t
Molecular iodine catalyzed transfer hydrogenation: Reduction of aldimines, ketimines, and α-imino esters
Bachu, Prabhakar,Zhu, Chen,Akiyama, Takahiko
supporting information, p. 3977 - 3981 (2013/07/25)
An efficient and practical protocol for the reduction of aldimines, ketimines, and α-imino esters in the presence of catalytic amount of molecular iodine with Hantzsch ester at ambient temperature afforded the corresponding amines in excellent yields.
