2633-50-3

Usage

InChI:InChI=1/C10H11BrO/c1-7-3-4-9(5-8(7)2)10(12)6-11/h3-5H,6H2,1-2H3

Upstream product

• 95-47-6 o-xylene 
• 598-21-0 2-Bromoacetyl bromide 
• 108773-84-8 3-Bromomethyl-3-(3,4-dimethyl-phenyl)-4,4-dimethyl-[1,2]dioxetane 
• 3637-01-2 3,4-dimethylacetophenone 

Downstream Products

• 85018-99-1 1-(3,4-dimethyl-phenacyl)-pyridinium; bromide 
• 385815-40-7 2-(3,4-dimethyl-phenyl)-indolizine 
• 313528-18-6 2-(3,4-dimethylphenyl)imidazo[1,2-a]pyridine 
• 110179-23-2 2-(3,4-dimethyl-phenyl)-imidazo[1,2-a]pyrimidine 
• 6097-19-4 1-(3,4-dimethylphenyl)-2-thiocyanatoethan-1-one 
• 109470-04-4 2-(3,4-dimethyl-phenyl)-5-methoxy-indole 
• 739302-02-4 1-(3,4-dimethyl-phenyl)-2-(2-imino-thiazol-3-yl)-ethanone 
• 103793-35-7 1-Methyl-3-[2-(3,4-dimethylphenyl)-2-oxoethyl]-1H-imidazolium bromide 
• 129972-99-2 N-[2-(3,4-Dimethyl-phenyl)-2-oxo-ethyl]-formamide 
• 129972-95-8 C₁₂H₁₃NO₃ 
• 90874-60-5 ω-Amino-3,4-dimethyl-acetophenon 
• 113813-43-7 Phosphoric acid 1-(3,4-dimethyl-phenyl)-vinyl ester dimethyl ester 
• 113813-45-9 Phosphoric acid 1-(3,4-dimethyl-phenyl)-vinyl ester diethyl ester 
• 20973-21-1 ω-(dibenzylamino)-3,4-dimethylacetophenone 

Relevant academic research and scientific papers

Polysubstituted Ligand Framework for Color Tuning Phosphorescent Iridium(III) Complexes

A series of ligands have been synthesized based upon a polysubstituted 2-phenylquinoxaline core structure. These ligands introduce different combinations of fluorine and methyl substituents on both the phenyl and quinoxaline constituent rings. The resultant investigation of these species as cyclometalating agents for Ir(III) gave cationic complexes of the form [Ir(C^N)2(bipy)]PF6 (where C^N = cyclometalating ligand; bipy = 2,2′-bipyridine). X-ray crystallographic studies were conducted on four complexes and each revealed the expected distorted octahedral geometry based upon a cis-C,C and trans-N,N ligand arrangement at Ir(III). Supporting computational studies predict that each of the complexes share the same general descriptions for the frontier orbitals. TD-DFT calculations suggest MLCT contributions to the lowest energy absorption and a likely MLCT/ILCT/LLCT nature to the emitting state. Experimentally, the complexes display tunable luminescence across the yellow-orange-red part of the visible spectrum (λem = 579-655 nm).

Enantioselective Synthesis of Nitrogen-Nitrogen Biaryl Atropisomers via Copper-Catalyzed Friedel-Crafts Alkylation Reaction

Nitrogen-nitrogen bonds containing motifs are ubiquitous in natural products and bioactive compounds. However, the atropisomerism arising from a restricted rotation around an N-N bond is largely overlooked. Here, we describe a method to access the first enantioselective synthesis of N-N biaryl atropisomers via a Cu-bisoxazoline-catalyzed Friedel-Crafts alkylation reaction. A wide range of axially chiral N-N bisazaheterocycle compounds were efficiently prepared in high yields with excellent enantioselectivities via desymmetrization and kinetic resolution. Heating experiments showed that the axially chiral bisazaheterocycle products have high rotational barriers.

SUBSTITUTED DIHYDROPYRAZOLO PYRAZINE CARBOXAMIDE DERIVATIVES

The invention relates to substituted dihydropyrazolo pyrazine carboxamide derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.

Efficient sulfonylation of ketones with sodium sulfinates for the synthesis of β-keto sulfones

The oxidative sulfonylation of ketones with sodium sulfinates as the sulfone source and DMSO as the oxidant is reported. A series of β-keto sulfones were obtained in good to excellent yields. The advantages of this efficient protocol include the low cost of DMSO and HBr, and a broad scope.

DERIVATIVES OF BENZOTHIAZINES, PREPARATION THEREOF AND APPLICATION THEREOF AS DRUGS

The object of the present invention is benzothiazine derivatives having the capability of inhibiting 11β-HSD1 not only at an enzymatic level but also at a cell level. The compounds of the present invention are of general formula (I). Wherein notably R1 represents a hydrogen or OR1 represents an ester or an ether. R2 represents a naphthyl or a 1, 2, 3, 4-tetrahydro-naphthalene or a biphenyl or phenyl pyridine or a substituted phenyl. R3 represents a methyl or ethyl; R4 and R'4 represent a hydrogen.

SUBSTITUTED THIAZOLE DERIVATIVES BEARING 3-PYRIDYL GROUPS, PROCESS FOR PREPARING THE SAME AND USE THEREOF

The present invention provides a pharmaceutical composition having a steroid C17,20-lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism, tumor such as breast cancer and the like, more particularly, a steroid C17,20-lyase inhibitor containing a compound represented by the formula: wherein A1 is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, one of A2 and A3 is a hydrogen atom, a halogen atom, a C1-4 aliphatic hydrocarbon group optionally having substituents or an optionally esterified carboxyl group, the other of A2 and A3 is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, and at least one of A1, A2 and A3 is a 3-pyridyl group optionally having substituents, or a salt thereof or a prodrug thereof.

Antifungal amine derivatives and processing for producing the same

Novel amine derivatives having an excellent antimycotic effect represented by general formula (1) below and salts thereof are provided. [in the formula (1, R1represents a C1-5alkyl group which may be halogenated, R2represents 4-(1,1-dimethylalkyl)benzyl group, 4-(1-methyl-phenylethyl)benzyl group, 1-or 2-naphthylmethyl group, or a hydrocarbon group having 3,3-dimethyl-1-butynyl group or a phenyl group at its terminal and 1 to 3 double bonds; R3represents oxygen atom or a methylene group which may be substituted by a C1-4alkyl group; and R4represents 1-or 2 naphthyl group or a phenyl group which may be substituted.

Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents

An efficient combinatorial route to substituted 3-phenyl-benzofurans, is achieved by the bromination of acetophenones to α-bromoacetophenones by polymer-supported pyridinium bromide perbromide (PSPBP). The subsequent clean substitution of the obtained bromides by phenols using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD-P) and cyclodehydration of the resulting α-phenoxyacetophenones using Amberlyst 15, affords pure products without the need for any chromatographic purification step.

Substituent Effects upon Efficiency of Excited-State Acetophenones Produced on Thermolysis of 3,4-Diaryl-3,4-dimethyl-1,2-dioxetanes

The effects of meta and para substituents upon the triplet (αT) and singlet (αS) efficiencies in the thermolysis of 3,4-diaryl-3,4-dimethyl-1,2-dioxetanes 3, 3-aryl-3,4,4-trimethyl-1,2-dioxetanes 4, and 3-aryl-3-(bromomethyl)-4,4-dimethyl-1,2-dioxetanes 5 are reported.Triplet efficiencies for series 3 dioxetanes, where the two proketone moieties are identical, are sensitive to aryl substituent changes.Attempted correlation of log αT with Hammett-type substituents constants failed, and the best correlation of log αT was with the lowest triplet energy of the acetophenones T) = (0.77+/-0.19)ET1(ArCOCH3)-55.05+/-14.00, r=0.834, Sy*x=+/-0.336>.This type of correlation was previously observed with 3-aryl-3-methyl- and 3-aryl-3-methyl-3,3-(2,2'-biphenyldiyl)-1,2-dioxetanes, where the slopes (S values) are 0.38+/-0.14 and 0.52+/-0.08, respectively.In these two dioxetane series, the triplet energies of the companion proketones (formaldehyde and fluorenone) to ArCOCH3 are approximately equal to and less than ET1(ArCOCH3).For the 4 and 5 series dioxetanes, there was no change in triplet efficiency with various aryl substituents, where the average αT values are 29.1+/-2.4percent for 4 and 28.1+/- 0.7percent for 5.For these two dioxetane series, the triplet energy of the companion proketone (acetone) is higher than ET1(ArCOCH3).With regard to triplet efficiencies, all of these dioxetane series fall into two categories: (i) where the companion proketones possess triplet energies approximately equal to or less than ET1(ArCOCH3) and where αT is dependent upon substituent changes in the ArCOCH3 moiety; (ii) where the companion proketone possesses a triplet energy higher than ET1(ArCOCH3) and αT is independent of substitution changes in the ArCOCH3 moiety.An exciplex or encounter complex process is proposed to explain the apparent communication between the two proketone moieties in category i dioxetanes.Activation parameters for series 3-5 were typical of most other tetrasubstituted dioxetanes.The ρ values for ?+ correlations of series 3 and 4 plus 5 dioxetanes are -0.285 +/- 0.033 and -0.20 +/- 0.05, respectively, which is consistent with a 1,4-dioxy biradical decomposition process.