3637-01-2

Basic information

• Product Name: 3',4'-Dimethylacetophenone
• Synonyms: 1-Acetyl-3,4-dimethylbenzene;Methyl(3,4-xylyl) ketone;3',4'-Dimethylacetophenone,97%;ASISCHEM D29254;3',4'-DIMETHYLACETOPHENONE;3,4-DIMETHYLACETOPHENONE;(3,4-DIMETHYLPHENYL)ETHANONE;1-(3,4-Dimethylphenyl)ethan-1-one
• CAS NO: 3637-01-2
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.2
• EINECS: 222-859-2
• Product Categories: Ketones;Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;C10;Carbonyl Compounds
• Mol File: 3637-01-2.mol
• Article Data: 45

Chemical Properties

• Melting Point: -1.5°C
• Boiling Point: 243 °C(lit.)
• Flash Point: 217 °F
• Appearance: clear colourless to light yellow liquid
• Density: 1.001 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.538(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 907053
• CAS DataBase Reference: 3',4'-Dimethylacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-Dimethylacetophenone(3637-01-2)
• EPA Substance Registry System: 3',4'-Dimethylacetophenone(3637-01-2)

Safety Data

• Hazard Codes: Xn
• Statements: 36-20/22
• Safety Statements: 39-26-24/25
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 3637-01-2(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless to light yellow liquid

Uses

3′,4′-Dimethylacetophenone was used as starting reagent in the synthesis of 4-[5-(3,4-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenecarboxyamide.

Upstream product

• 1195-79-5 1,3,3-trimethyl-2-norbornanone 
• 2142-73-6 1-(2,5-dimethylphenyl)-1-ethanone 
• 64-19-7 acetic acid 
• 619-04-5 3,4-dimethylbenzoic acid 
• 50690-08-9 2-chloro-1-(3,4-dimethyl-phenyl)-ethanone 
• 122-52-1 triethyl phosphite 
• 95-47-6 o-xylene 
• 127-17-3 2-oxo-propionic acid 
• 69849-04-3 2-(1-ethoxyethoxy)-2-lithiopropanenitrile 
• 7446-70-0 aluminium trichloride 
• 89-74-7 2,4-dimethylacetophenone. 
• 7727-15-3 aluminium bromide 
• 108-68-9 3,5-Dimethylphenol 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 20389-06-4 2-(3,4-dimethyl-phenyl)-quinoline-4-carboxylic acid 
• 22422-23-7 3-chloro-1-(3,4-dimethyl-phenyl)-propan-1-one 
• 104296-00-6 N-(2-hydroxybenzylidene)anthranilic acid 
• 93016-39-8 1-(3,4-dimethyl-phenyl)-ethanone-(2,4-dinitro-phenylhydrazone) 
• 79219-37-7 1-(3,4-dimethyl-phenyl)-3-piperidino-propan-1-one; hydrochloride 
• 412018-89-4 3-(3,4-dimethyl-phenyl)-2-methyl-butyric acid 
• 871896-99-0 δ-oxy-δ-(3.4-dimethyl-phenyl)-α-amylene 
• 112689-10-8 (3,4-dimethyl-phenyl)-glyoxal-2-oxime 
• 15089-82-4 1-(4,5-dimethyl-2-nitrophenyl)ethanone 
• 49666-83-3 1-(3,4-dimethyl-2-nitro-phenyl)-ethanone 
• 934-80-5 1,2-dimethyl-4-ethylbenzene 
• 91817-69-5 3',4'-dimethylacetophenone oxime 
• 17283-16-8 3,4-dimethylphenylacetic acid 
• 95-64-7 4-amino-o-xylene 

Relevant articles and documents

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Photoinduced Acetylation of Anilines under Aqueous and Catalyst-Free Conditions

A green and efficient visible-light induced functionalization of anilines under mild conditions has been reported. Utilizing nontoxic, cost-effective, and water-soluble diacetyl as photosensitizer and acetylating reagent, and water as the solvent, a variety of anilines were converted into the corresponding aryl ketones, iodides, and bromides. With advantages of environmentally friendly conditions, simple operation, broad substrate scope, and functional group tolerance, this reaction represents a valuable method in organic synthesis.

Metal-Free Photoinduced Transformation of Aryl Halides and Diketones into Aryl Ketones

The acylation of aryl halides to prepare aryl ketones without metal catalyst represents an important yet challenging topic towards more sustainable ketone synthesis. Herein, we describe a simple and efficient metal-free protocol for the acylation of aryl halides with diketone under the irradiation of light utilizing N-methylpiperidine as base under an air atmosphere. This reaction can tolerate a wide range of functional groups and the corresponding ketones can be obtained in modest to good yields.