263349-22-0

Usage

Uses

Used in Organic Synthesis:
3-(PYRIMIDIN-2-YL)BENZALDEHYDE is used as a building block in organic synthesis for the development of a variety of complex organic compounds. Its unique structure, which includes both a benzene and a pyrimidine ring, contributes to its utility in creating diverse chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-(PYRIMIDIN-2-YL)BENZALDEHYDE is utilized as a key intermediate in the synthesis of new drugs. Its presence in the molecular structure of potential drug candidates can influence their pharmacological properties, making it an important component in drug discovery and development processes.
Used in Dye Production:
3-(PYRIMIDIN-2-YL)BENZALDEHYDE also finds application in the production of dyes due to its chemical properties. The ability to form various colored compounds makes it a useful intermediate in the creation of dyes for different industries, including textiles and printing.
Overall, the presence of both a benzene ring and a pyrimidine ring in 3-(PYRIMIDIN-2-YL)BENZALDEHYDE's structure endows it with a broad range of applications across multiple industries, highlighting its significance in modern chemical and pharmaceutical research.

InChI:InChI=1/C11H8N2O/c14-8-9-3-1-4-10(7-9)11-12-5-2-6-13-11/h1-8H

Upstream product

• 7431-45-0 2-phenylpyrimidine 
• 75-25-2 Bromoform 
• 1722-12-9 2-chloropyrimidine 
• 87199-16-4 3-Formylphenylboronic acid 
• 4595-60-2 2-bromopyrimidine 

Downstream Products

• 263349-23-1 (3-phenoxy-phenyl)-(3-pyrimidin-2-yl-benzyl)-amine 
• 1224437-61-9 4-chloro-3-(pyrimidin-2-yl)benzaldehyde 
• 1224437-62-0 2,4-dichloro-3-(pyrimidin-2-yl)benzaldehyde 
• 579476-25-8 3-pyrimidin-2-yl benzoic acid methyl ester 
• 892502-12-4 (3-(pyrimidin-2-yl)phenyl)methanol 
• 898289-51-5 2-(3-(chloromethyl)phenyl)pyrimidine 
• 898289-50-4 3-(pyrimidin-2-yl)benzonitrile 
• 1396789-56-2 C₂₉H₃₁ClN₄OS 
• 1246561-74-9 (3-(pyrimidin-2-yl)phenyl)methylene diacetate 

Relevant academic research and scientific papers

Preparation method of meta-aromatic aldehyde (by machine translation)

The method, uses an aromatic compound as a raw material, to prepare,bromocarbon, ruthenium catalyst, base and a solvent, wherein the solvent is acetonitrile or, dioxane, which is used as an acylating reagent; to obtain m-substituted aromatic aldehyde; by stirring heating temperature to 1,4 - reaction;hour, separation product in the presence of an alkali, additive, solvent, catalyst. 110 - 130 °C, and a solvent is directly added to the reaction device to obtain a meta-substituted aromatic aldehyde. 20 - 25, The method is convenient and low in cost, by using cheap and C - H easily C - H available, carbon tribromide as an acylating agent under. the ruthenium catalysis action. and a solvent. (by machine translation)

Ruthenium-Catalyzed meta-Selective CAr-H Bond Formylation of Arenes

The meta-CAr-H bond formylation of arenes has been achieved using CHBr3 as a formyl source in the presence of [Ru(p-cym)(OAc)2] as a catalyst. This method provides efficient access to the preparation of various meta-substituted aromatic compounds, such as alcohols, ethers, amines, nitriles, alkenes, halogens, carboxylic acids, and their derivatives, through transformation of the versatile formyl group. Furthermore, mechanistic studies show that the key active species is a pentagonal ruthenacycle complex.

Method for preparing meta-position alkenyl aromatic compound

The invention discloses a method for preparing a meta-position alkenyl aromatic compound. The meta-position alkenyl aromatic compound is prepared from a meta-position formyl aromatic compound and diethyl benzylphosphonate through a reaction, and the reaction comprises steps of directly adding the meta-position formyl aromatic compound, the diethyl benzylphosphonate, ammonium acetate, iodine, peroxytert-butanol, sodium carbonate and ethanol into a reaction device, performing stirring and heating to a temperature of 45-55 DEG C, performing the reaction for 7-9 hours, and separating products, soas to obtain the meta-position alkenyl aromatic compound. By adopting the method, the meta-position alkenyl aromatic compound can be conveniently and rapidly synthesized.

Preparation method of meta-position cyano-aromatic compound

The invention provides a preparation method of a meta-position cyano-aromatic compound. The meta-position cyano-aromatic compound is obtained by performing reaction on a meta-position formyl-aromaticcompound serving as a raw material and ammonium acetate. The preparation method comprises the following steps: directly adding the meta-position formyl-aromatic compound, the ammonium acetate, iodine,tert-butanol hydrogen peroxide, sodium carbonate and ethanol into a reaction device, stirring and heating to 45 to 55 DEG C, performing reaction for 7 to 9 hours and separating products to obtain themeta-position cyano-aromatic compound. Through the reaction, the meta-position cyano-aromatic compound can be obtained conveniently and rapidly.

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure-activity relationship of this important class of hedgehog-pathway inhibitors.

Palladium-catalyzed monoselective halogenation of C-H bonds: Efficient access to halogenated arylpyrimidines using calcium halides

A wide variety of ortho-halogenated arylpyrimidines were prepared with high monoselectivity and functional-group tolerance by using calcium halides as crucial halogenating agents and cupric trifluoroacetate as oxidant in the presence of air.

Palladium-Catalyzed Regioselective C-H Bond ortho-Acetoxylation of Arylpyrimidines

An efficient and regioselective palladium-catalyzed ortho C-H acetoxylation reaction was developed to afford, ortho monoacetoxylated arylpyrimidmes in good to excellent yields by using cupric trifluoroacetate as a cocatalyst. A wide variety of oxygenated

6-O-acyl ketolide antibacterials

6-O-Acyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, W, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

6-O-carbamate-11,12-lacto-ketolide antimicrobials

6-O-Carbamate-11,12-lacto-ketolide antimicrobials of the formula: wherein R1, R2, R3 R7, and R8 are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

6-O-carbamoyl ketolide antibacterials

6-O-Carbamoyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, R5, R6, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.