263358-30-1Relevant academic research and scientific papers
Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective α(1a)-adrenergic receptor antagonists
Lagu, Bharat,Tian, Dake,Chiu, George,Nagarathnam, Dhanapalan,Fang, James,Shen, Quanrong,Forray, Carlos,Ransom, Richard W.,Chang, Raymond S. L.,Vyas, Kamlesh P.,Zhang, Kanyin,Gluchowski, Charles
, p. 175 - 178 (2007/10/03)
Furo[3,4-d]pyrimidinones were found to be metabolites of dihydropyrimidinones such as 1a-b that are subtype-selective antagonists of the α(1a)-adrenergic receptor. A versatile synthesis that provides access to furo[3,4-d]pyrimidinones in high yield and in enantiomerically pure forms is described along with structure-activity relationships in the series.
